The modern trends of human lifestyle contributed significantly to increased incidence of many undesirable conditions of mainly inferior life quality due to metabolic and nervous diseases, morbidities and mortalities [1,2]. Impaired timing of foods and fruits-vegetables intake is a key reason for such a global disaster. Not eating adequate and healthy breakfast and taking unhealthy fast foods during the stressful and overly busy day times seriously threat gut health, which is exacerbated by inappropriate timing and choices of evening meals [3-5].

The living gut requires regaining its active physiology post-nocturnal-sleep when activity begins in early morning. Exercise has long been considered as an excellent inducer of healthy metabolism to prepare the entire body for the upcoming active phase [6]. However, gut also needs sufficient exercise that is partly supplied by early morning physical activity, which must be complemented through timely intake of fibrous fruits, such as skinned apple and cucumber as well as fresh leaves and stems of a variety of vegetables. This early morning intake of fibrous and partly energizing brief meals ensures that physical activity suitably serves the gut physiology and health towards a motivating and relaxing day of intense activity. This phenomenon must be responsibly educated and disseminated worldwide for its practical consequences to be effectively realized [7,8].

Later on at the end of the activity period when evening begins, large starchy and fatty meals must be avoided and instead brief foods should be supplemented with fresh vegetables and fruits. The evening consumption of such a fibrous and vitamin-mineral-rich meal will soon induce satiety via both physical and chemical constraints. As a result, overintake of energy and chances for adiposity and obesity are minimized, thereby helping the body to be more resistant against risk factors of diabetes and related metabolic and cardiovascular abnormalities. As a rule of thumb, one skinned apple at the commencement and another at the end of wake daily period should be taken (i.e., just after morning wake-up and just before nocturnal sleep). Fresh and cell wall-rich vegetables of mainly stems and leaves must also be taken to ensure stimulating sufficient gut mechanics. Public education must be persistently exercised to optimally disseminate knowledge and insight for timely practice. Such a pragmatic science drives the modernized human to move back towards nature where internal rhythms of human physiology are optimally synchronized and harmonized with environmental cues [9-11]. This is a real probiotic for optimal gut physiology and entire body performance.

Optimizing the circadian patterns of fruits and vegetables intake is a gut-exerciser probiotic that must be accommodated in modern and postmodern public health and nutrition programs. Starting and terminating the wake daily period with fibrous and relatively energizing fruits and vegetables consumption induces optimal gut dynamics while helping to minimize risks of energy overingestion, obesity, diabetes, and metabolic and cardiovascular comorbidities.

Thanks to the Ministry of Science Research and Technology, National Elite Foundation, and University of Zanjan for supporting the author’s global initiatives and programs of optimizing science edification in the third millennium.