Journal of Hematology & Thromboembolic Diseases
Open Access

Distinctions and Delimitations between Hematopoietic Progenitor Cells and Hematopoietic

Ayofemi Obi^{* *}Correspondence: Ayofemi Obi, Deparment of Clinical Laboratory, University of Ibadan, Ibadan, Nigeria, Email:

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Description

Hematopoietic stem cells have the capacity to differentiate into a variety of cell types, whereas progenitor cells are more focused and differentiate into target cells. This is the main distinction between the two types of cells. In the human body, stem cells can differentiate into a wide variety of cell types and expand unabatedly. Hematopoietic stem cells are undeveloped cells that give rise to all different kinds of blood cells. Stem cells give rise to progenitor cells, which undergo additional cell type differentiation.

Hematopoietic stem cells

In order to function, Hematopoietic Stem Cells (HSCs) depend on a variety of paracrine signals that are produced by the liver and certain microenvironments in the bone marrow. While hepatocyte-produced thrombopoietin and other long-range acting signals, such as Stem Cell Factor (SCF) and CXCL12, can be accessed by HSCs presumably anywhere, perisinusoidal Mesenchymal Stem/Progenitor Cells (MSPCs) and Endothelial Cells (ECs) in the bone marrow preferentially access these signals. Though historically referred to as hematopoietic stem cell niches, more recent research have shown that these niches are also essential for the growth of B-lymphoid lineage cells since MSPCs and ECs are the only cells that can produce IL7, a crucial lymphopoietic cytokine.

Single-cell RNA sequencing of non-hematopoietic bone marrow cell populations has revealed that in addition to the cytokines IL7, CXCL12, and SCF, MSPCs and ECs also express a number of important hematopoietic cytokines with well-defined roles in myeloid and lymphoid-lineage cell differentiation, including FLT3L, MCSF, IL34, IL15, and GCSF among.

Hematopoietic progenitor cells

In the formation of blood cells, Hematopoietic Progenitor Cells (HPCs) serve as a transitional cell type. Hematopoietic stem cells, which have the ability to self-renew and differentiate into hematopoietic progenitor cells, give rise to HPCs, which are immature cells. Over 10 different types of adult blood cells can eventually be formed from HPCs.

Based on their cell potency, or differentiation potential, hematopoietic progenitor cells are divided into different types. Blood cells lose potency as they mature. The process of multipotent progenitor cell differentiation begins with hematopoietic stem cells. A subset of cell types can be formed from multipotent progenitor cells, which have this ability. Following differentiation, these cells become either Common Lymphoid Progenitor (CLP) or Common Myeloid Progenitor (CMP) (CLP). Types of oligopotent progenitor cells include CMPs and CLPs (progenitor cells that differentiate into only a few cell types). As cell lines, CMPs and CLPs continue to differentiate, they become lineage-restricted progenitor cells that eventually develop into mature blood cells.

Conclusion

The peripheral blood and bone marrow both contain immature cells called hematopoietic stem cells. Through a process known as hematopoiesis, they have the capacity to produce every type of blood cell, including platelets, red blood cells, and white blood cells. Stem cells give rise to progenitor cells, which can then differentiate to produce specific cell types. Each progenitor cell can differentiate into a cell that belongs to the same tissue or organ. In numerous cell-based therapies, including tissue regeneration and transplantation, HSCs and progenitor cells are both useful. As a result, this describes how hematopoietic stem cells and progenitor cells differ from one another.