Journal of Sleep Disorders & Therapy
Open Access

Exposing the Causes of Obstructive Sleep Apnea: Understanding the Silent Disruptor

Diogo Abreu^{* *}Correspondence: Diogo Abreu, Department of Neuroscience, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal, Email:

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Description

Obstructive Sleep Apnea (OSA) is a prevalent yet often undiagnosed sleep disorder that disrupts breathing during sleep. Characterized by repetitive episodes of partial or complete upper airway obstruction, OSA poses significant health risks and impacts daily functioning. This article explores the multifaceted causes of OSA, shedding light on the factors that contribute to this condition.

Anatomy of obstructive sleep apnea

Before delving into its causes, it's important to grasp the mechanics of OSA [1]. During sleep, the muscles in the throat relax, causing the airway to narrow or close as breathing becomes shallow or pauses altogether. This obstruction leads to drops in oxygen levels and disruptions in sleep patterns, often accompanied by loud snoring or choking sensations as breathing resumes [2].

Physical factors

Anatomical abnormalities: Structural issues in the upper airway can predispose individuals to OSA. These include enlarged tonsils or adenoids, a narrow throat, a large tongue, or a small jaw relative to the size of the tongue. Such abnormalities can obstruct the airway more easily during sleep, contributing to breathing difficulties [3].

Excess weight: Obesity is a significant risk factor for OSA. Excess fat around the neck and upper airway can compress the airway, making it more susceptible to collapse during sleep. Fat deposits in the abdomen can also affect diaphragm movement, further complicating breathing patterns [4].

Age and gender: OSA is more prevalent in older adults due to natural muscle tone loss and changes in airway structure with age. Men are also at higher risk than women, although the risk for women increases after menopause, likely due to hormonal changes [5-6].

Lifestyle and behavioral factors

Smoking and alcohol use: Both smoking and excessive alcohol consumption can relax the muscles in the throat, increasing the likelihood of airway obstruction. Alcohol, in particular, can lead to more frequent and severe episodes of apnea during sleep.

Sedative use: Certain medications and sedatives, including muscle relaxants and tranquilizers, can relax the throat muscles excessively, contributing to airflow obstruction during sleep [7].

Medical conditions

Hypertension and cardiovascular disease: There is a bidirectional relationship between OSA and cardiovascular conditions. Hypertension and heart disease can exacerbate OSA symptoms, while untreated OSA can contribute to elevated blood pressure and cardiovascular strain.

Diabetes: Individuals with diabetes are at higher risk of developing OSA, possibly due to metabolic changes affecting upper airway function. The presence of both conditions can worsen each other's symptoms and complications [8].

Neurological disorders: Conditions that affect central nervous system control of breathing, such as stroke or Parkinson's disease, can increase the likelihood of OSA by disrupting the brain's regulation of respiratory patterns during sleep.

Genetic and familial factors

Family history: There appears to be a genetic predisposition to OSA. Individuals with family members who have OSA may be at higher risk due to inherited traits related to airway anatomy and muscle tone regulation [9].

Environmental factors

Airway irritants: Exposure to pollutants, allergens, or irritants in the air can contribute to inflammation and swelling of the airway lining, increasing the likelihood of obstruction during sleep [10].

Conclusion

Obstructive Sleep Apnea is a complex sleep disorder with a range of contributing factors, from physical anatomy and lifestyle choices to underlying medical conditions and genetic predispositions. Recognizing these causes is important for early detection and effective management of OSA, as untreated sleep apnea can lead to serious health consequences, including cardiovascular disease, cognitive impairment, and reduced quality of life. By addressing risk factors such as obesity, smoking, and sedative use, individuals can mitigate their chances of developing OSA or alleviate its severity. Additionally, seeking medical evaluation for symptoms such as loud snoring, excessive daytime sleepiness, or observed breathing pauses during sleep is essential for timely diagnosis and appropriate treatment. Through awareness and proactive management, individuals can reclaim restful sleep and safeguard their overall health and well-being.

References

1. Kamdar BB, Needham DM, Collop NA. Sleep deprivation in critical illness: Its role in physical and psychological recovery. J Intensive Care Med. 2012;27(2):97-111.

   [Crossref] [Google Scholar] [PubMed]

2. McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M et al. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009;49(10):868-913.

   [Crossref] [Google Scholar] [PubMed]

3. Micic G, Zajamsek B, Lechat B, Hansen K, Scott H, Toson B, et al. Establishing the acute physiological and sleep disruption characteristics of wind farm versus road traffic noise disturbances in sleep: A randomized controlled trial protocol. Sleep Adv. 2023;4(1):zpad033. [Crossref]

   [Google Scholar] [PubMed]

4. Leisegang K, Henkel R, Agarwal A. Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system. Am J Reprod Immunol. 2019;82(5):e13178.

   [Crossref] [Google Scholar] [PubMed]

5. Baillie GS, Tejeda GS, Kelly MP. Therapeutic targeting of 3′, 5′-cyclic nucleotide phosphodiesterases: Inhibition and beyond. Nat Rev Drug Discov. 2019;18(10):770-796.

   [Crossref] [Google Scholar] [PubMed]

6. Homolak J, Mudrovčić M, Vukić B, Toljan K. Circadian rhythm and Alzheimer’s disease. Med Sci. 2018;6(3):52.

   [Crossref] [Google Scholar] [PubMed]

7. Bliss TV, Collingridge GL, Morris RG. Synaptic plasticity in health and disease: Introduction and overview. Philos Trans R Soc Lond B Biol Sci. 2014;369(1633):20130129.

   [Crossref] [Google Scholar] [PubMed]

8. Guerra JV, Dias MM, Brilhante AJ, Terra MF, Garcia-Arevalo M, Figueira AC, et al. Multifactorial basis and therapeutic strategies in metabolism-related diseases. Nutrients. 2021;13(8):2830.

   [Crossref] [Google Scholar] [PubMed]

9. Persiani SG, Kobas B, Koth SC, Auer T. Biometric data as real-time measure of physiological reactions to environmental stimuli in the built environment. Energies. 2021;14(1):232.

   [Google Scholar]

10. Monayo SM, Liu X. The prospective application of melatonin in treating epigenetic dysfunctional diseases. Front Pharmacol. 2022;13:867500.

    [Crossref] [Google Scholar] [PubMed]