Journal of Clinical & Experimental Dermatology Research
Open Access

Illuminating Eczema: A Comprehensive Assessment of Phototherapy Efficacy–A Systematic Review and Meta-Analysis

Dong Jie^{* *}Correspondence: Dong Jie, Department of Traditional Chinese Medicine Dermatology, Shanghai University of Traditional Chinese Medicine, Shanghai, China, Email:

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Description

Eczema, characterized by chronic inflammation of the skin, poses a substantial health burden, prompting a continuous quest for effective therapeutic interventions. Phototherapy, employing various wavelengths of light, has emerged as a effective remedies for eczema management [1]. This short communication provides a succinct overview of our systematic review and meta-analysis, aimed at evaluating the efficacy of phototherapy in the treatment of eczema. By meticulously synthesizing data from relevant studies, we aim to address on the current state of evidence regarding the effectiveness of phototherapy modalities. Our findings contribute to the evolving environment of eczema treatment and may inform clinical decisions in harnessing the potential of phototherapy. Eczema, also known as atopic dermatitis, is a prevalent and distressing skin condition characterized by inflammation, pruritus, and impaired skin barrier function [2]. Despite various treatment options, achieving long-term control remains challenging. Phototherapy, involving the controlled exposure of the skin to specific wavelengths of light, has gained attention as a potential therapeutic strategy. Our review seeks to provide a comprehensive evaluation of the efficacy of phototherapy in managing eczema, considering the diverse modalities within this treatment approach [3]. Our systematic review followed established guidelines, including a predefined protocol, comprehensive literature searches, and rigorous eligibilitywith NB-UVB, suggest that phototherapy merits consideration as a viable therapeutic option. This concise communication aims to inform clinicians, researchers, and stakeholders about the evolving landscape of eczema management, emphasizing the potential role of phototherapy in improving patient outcomes. criteria. We conducted a thorough search across major databases for randomized controlled trials and observational studies evaluating the impact of phototherapy on eczema outcomes. Studies assessing Narrowband Ultraviolet B (NB-UVB), Ultraviolet A (UVA), and other phototherapeutic interventions were included. A total of studies met the inclusion criteria, encompassing diverse patient populations and phototherapy modalities. The primary outcomes included improvement in pruritus, erythema, disease severity, and quality of life. Subgroup analyses were conducted to assess the specific efficacy of NBUVB, UVA, and other variations of phototherapy.

Phototherapy modalities

Our analysis revealed that NB-UVB demonstrated consistent efficacy in reducing pruritus and disease severity across various studies. UVA and other phototherapy variations also exhibited positive outcomes, albeit with some variability. Subgroup analyses stratified by age groups and disease severity provided insights into the differential response to phototherapy among diverse patient cohorts [4].

Safety Profile: Assessment of the safety profile revealed a generally well-tolerated intervention. Adverse effects, such as erythema and xerosis, were mild and transient in nature. Longterm safety considerations were explored, highlighting the importance of balancing therapeutic benefits with potential risks. Our findings underscore the potential of phototherapy as a valuable component in the multifaceted management of eczema. The observed efficacy aligns with the immunomodulatory and anti-inflammatory effects of specific wavelengths of light. Furthermore, the safety profile of phototherapy enhances its attractiveness as a treatment option, particularly for individuals who may be resistant or intolerant to conventional therapies.

While our review contributes valuable insights, further research is warranted to address specific gaps in the current literature. Future studies could explore optimal dosing regimens, long-term outcomes, and the comparative effectiveness of different phototherapy modalities. Additionally, investigating the impact of phototherapy on specific subtypes of eczema may provide customized treatment recommendations. Overall, continued exploration of phototherapy's role in eczema management holds potential for enhancing our understanding and refining treatment approaches in the future [5].

Conclusion

In conclusion, our systematic review and meta-analysis provide a comprehensive evaluation of the efficacy of phototherapy in eczema treatment. The positive outcomes observed, particularly with NB-UVB, suggest that phototherapy merits consideration as a viable therapeutic option. This concise communication aims to inform clinicians, researchers, and stakeholders about the evolving landscape of eczema management, emphasizing the potential role of phototherapy in improving patient outcomes.

References

1. Musters AH, Mashayekhi S, Harvey J, Axon E, Lax SJ, Flohr C, et al. Phototherapy for atopic eczema. Cochrane Database Syst Rev. 2021;10.

   [Crossref] [Google Scholar] [PubMed]

2. Berke R, Singh A, Guralnick M. Atopic dermatitis: An overview. American family physician. 2012;86(1):35-42.

   [Google Scholar]

3. Jacob J, Pona A, Cline A, Feldman S. Home UV phototherapy. Dermatol Clin. 2020;38(1):109-126.

   [Crossref] [Google Scholar] [PubMed]

4. Reynolds NJ, Franklin V, Gray JC, Diffey BL, Farr PM. Narrow-band ultraviolet B and broad-band ultraviolet A phototherapy in adult atopic eczema: A randomised controlled trial. Lancet. 2001;357(9273):2012-2016.

   [Crossref] [Google Scholar] [PubMed]

5. Gambichler T, Othlinghaus N, Tomi NS, Holland‐Letz T, Boms S, Skrygan M, et al. Medium‐dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: A randomized crossover study. Br J Dermatol. 2009;160(3):652-658.

   [Crossref] [Google Scholar] [PubMed]