In addition to recognized risk factors environmental physical factors like Solar (SA), Geomagnetic (GMA), Cosmic Ray activity (CRA), space Proton flux and other forces are involved in regulation of human homeostasis and timing of medical emergencies [1-14].

In recent years a number of studies were published in relation of CRA and their activity units-Neutron activity on the Earth’s surface (in impulses per minute-imp/min and Acute Myocardial Infarction (AMI), Stroke (CVA), Sudden Cardiac Death (SCD) timing [1-17].

Most studies find links between the ting of the mentioned cardiovascular events and the level of CRA (Neutron) activity. We know that most AMI are a consequence of atheromatous plaque in the coronary arteries disruption, or fissuring (18-34) Physical agents can be a part of the process affecting the plaque.SA and GMA are natural shields against CRA and Neutron flux, and they are inverse related [28].

The aim of this study was to explore the dynamics of AMI morbidity on days of Zero GMA AND RESPECTIVELY HIGH LEVELS OF CRANeutron activity on this day and following days of the next post Zero GMA day.

We studied the number of admissions for AMI in the departments of Cardiology (including ICCU) in the Medical Science University hospital in Kaunas, Lithuania in years 2000-2007. 8920 patients were included in the study. The diagnosis of AMI was based on the guidelines of the European Society of Cardiology, including clinical, electrocardiography, echocardiography and enzymatic (Troponin, CPC etc.) criteria [34]. Daily GMA was checked. The studied period included 36 days of Zero GMA [28]. We calculated the average number of AMI at day of Zero GMA, first and second day post the Zero day and also, including Zero GMA day and 6 days, following the Zero day for all patients with AMI and for both gender separately.

We calculated the average daily Neutron activity for the whole 2000-2007 period and separately for the Zero GMA days.

The cosmophysical data about SA, GMA, and CRA was obtained from the National Oceanic Atmospheric Administration National Geophysical Data Center and Space Weather Prediction Centers, USA, IZMIRAN Institute of the Russian Academy of Sciences and Oulu University Neutron Monitoring station in Finland [26-30].

Statistics

Statistical significance of the compared average data for Neutrons and AMI and their standard deviation at days Zero GMA and following days was calculated.

Differences (in percents) between the number of AMI patients admitted at Zero GMA and these admitted at the first and second days post Zero day and six days after the Zero day are presented.

Table 1 presents AMI patients distribution on Zero GMA and one and two days after, and the following week- including the Zero day and six days after, excluding the Zero day.

Table 1: DAILY AMI (n-8920) ON DAYS (n-36) OF ZERO GMA/HIGH NEUTRON ACTIVITY AND A WEEK LATER. KAUNAS, LITHUANIA, 2000 – 2007.

Figure 1 presents the AMI admissions average daily on day Zero, first and second day and the average of 6 days following Zero GMA days. It’s also shown the difference in percents and statistical significance of average data at any of the compared days, or groups of days in ratio to number of AMI at the Zero GMA/high Neutron activity days. The daily number of AMI at days one and two post Zero rose at 23%; at six days post Zero – by 18.7% compared with the Zerohigh Neutron activity days. The difference was significant at p= 0.01- 0.008. It was also shown that the average daily Neutron activity in years 2000-2007 was 8883 +-518 imp/min. On Zero GMA days- 9247+- 402, imp/min.; p<0.0001- significantly higher at Zero GMA days. For the interrelationship between CRA (Neutron) activity and SA and GMA illustration we calculated their monthly links in the last 20 years: results are presented in Figure 2.

Figure 1:

Figure 2:

AMI is one of the most often presentations of Acute Coronary Events, a solid part of cardiovascular mortality. [27,12,33,34]. Not rare a initially minimal stenosis , not providing a serious hemodynamic treat in a very short time is transformed to a complete, or subtotal coronary artery occlusion with possible sudden death ,or necrobiosis of the excluded from arterial supply part of the myocardium, as a result of acute atherothombosis. [23] The basis for this, often catastrophic event in the culprit artery of AMI are, in most cases, disruption, or fissuring of a “vulnerable” atherosclerotic plaque, with secondary elements of inflammation and artery lumen thrombosis at the surface of the damaged plaque. [13-26].

Many risk factors, like dislipidemia, high blood pressure, diabetes, obesity, smoking, deficit of physical activity predispose the plaque to grow, to become amorphous in his structure, with his lipid cup composition predisposed to disruption and/ or fissuring. [20,25,26,23]. In the last decade a number of important studies about nigh energy CRA were published [35-39]. The level of CRA is measured by Neutron activity on the Earth’s surface: they are remains of atoms crushed by CRA in the higher space. In recent years many studies demonstrated the links between timing of AMI and environmental physical activity. In a recent of publications [1-7,41,42] of our and related groups it was shown, that AMI timing is connected with CRA- Neutron activity on the Earth surface. Neutron activity is inverse related to SA and GMA [28]. SA and GMA are serving as a natural shield against CRA.

This study was provided in conditions when one of the CRA – Neutron antagonists GMA is eliminated and conditions for Neutron action (activity) is improved. In the published studies many acute cardiac events like AMI, SCD, the culprit artery of AMI; AMI complications (cardiogenic shock, right ventricular infarction), life threatening cardiac arrhythmia were inverse related to four levels of GMA and correlated with CRA (Neutron) activity [1-12,17-27]; in this study the factor of GMA was eliminated.

This, in our opinion, could help demonstrate the role of physical action of Neutrons (measured in imp/min) in the plaque damaging process close to the hours or days leading to the acute event-AMI.

The studied eight years period included only 36 days of Zero GMA. This could affect the statistical significance of the results. But nevertheless they were highly significant. Clinical data of the next 3 years, when the number of Zero days from year 2000 until the end of year 2010 is now over 115 [27] will, in the future, serve a basis for new observations. The following Zero day raise of admissions of patients with AMI is an additional confirmation of the role of Neutrons in the process of plaque damage and development of AMI. The role of neutrons in the timing of SCD, life threatening arrhythmias, atherothrombosis in the LAD artery was demonstrated in publications of the recent years. [16,17,1-4].

What can be presumed about the way of Neutron action? One of the ways accepted in biological studies of Neutron action is they affinity to hydrogen and H+ ions (high in the lipid structures), transformation Neutrons to Protons and attacking the cellular nuclei [40,41], Also Neutron action targeting cellular DNA is presumed with following cellular damage [41]. Can we prevent such effects? One of possibilities, maybe, can include some artificial magnetic devices, that high risk patients can use at days of very low GMA and high Neutron activity. Here we must take in account that high GMA is also harmful, especially rising coagulation, inflammation indices, arterial blood pressure etc. [42,43].

Before such preventive magnetic shield at periods of high CRA (Neutron) activity can be used, additional titration of the level of strength of the magnetic field must be titrated. Also patients must be informed about high Neutron activity periods. The presented data is another step exploring the links between the surrounding physical activity and human homeostasis-a subject of studies in Clinical Cosmobiology [44,45,17].

Limitations of the study

When one of antineutron powers-GMA is excluded, the SA is still acting (but is changing in the 11-year SA cycle). An ideal picture of Neutron action would be without this power also. But it’s non natural way for such situation..

We mentioned that the relatively small number of Zero GMA days is diminishing the results of this study. We’ll try to prolong our studies.

At this stage many studies about coronary plaque’s are done using intravascular ultrasound. In the future possibilities to measure the plaque “life” using different sorts of nanotechnology will allow monitoring the pre-AMI metabolism and corpuscular effects much more precisely.

Days of high Neutron activity on the Earth surface and Zero Geomagnetic activity are followed by significant admission raise of patients with Acute Myocardial Infarction, most on the first two days, but remaining on next to Zero six days.

The results of Neutron activity correlation with increased number of AMI serve as a basis to presume that Neutron involvement in the atheroma - plaque damage in the human coronary arteries –the basic morphologic process in the pathogenesis of this Acute Cardiac Event.

Use of antagonistic to Neutron activity physical forces (magnetic fields?) Can be considered at days of high Neutron activity in high risk population.