Journal of Applied Pharmacy
Open Access

Plants that have Quinoline Alkaloid and their Biological Activity

Aliyu Ahmad^*, Usman Yarima, Ahmad A Ibrahim, Fatima Aminu Salihu, Ibrahim Goni and Zakari Yau Yunusa ^*Correspondence: Aliyu Ahmad, Department of Chemistry, University of Federal, Gashua, Nigeria, Email:

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Description

A group of naturally occurring substances called quinoline alkaloids is present in many different plant species. Due to their wide range of biological activities, including their anticancer, antimalarial, anti-inflammatory, and antiviral characteristics, they have drawn researchers ‘attention. Cinchona species, which are used to cure malaria and contain quinine and similar alkaloids, are another source of quinoline alkaloids. In addition to their therapeutic effects, quinoline alkaloids have also demonstrated promising results in the field of agro chemistry. Choisya ternata is another plant that contains alkaloids like skimmianine and is used in traditional medicine to treat fever and inflammation. This review focus on quinoline alkaloid isolated from some medicinal plants and the compounds were found to have pharmacological properties.

Quinoline alkaloids are a group of organic compounds that are present in several plant species. Their distinctive feature is a fused ring structure made up of two six-membered rings, one of which has an atom of nitrogen [1]. Quinine, which is generated from the bark of the cinchona tree and has been used for centuries to cure malaria, is one of the most well-known quinoline alkaloids [2-8]. Other quinoline alkaloids with medicinal potential include pyridoacridine alkaloids, which are found in a variety of plant species and have demonstrated activity against bacteria and viruses, and camptothecin, which is found in the Chinese tree Camptotheca acuminate and has shown promise as an anticancer agent [9].Medicinal plants are regarded as rich sources of components in the production of pharmaceutical drugs [10-18]. Bioactive phytocompounds found in medicinal plants are primarily employed for the treatment of many human diseases and also play a significant role in healing [19,20]. The health of humans, both individually and collectivesly, has depended on medicinal plants since antiquity [21]. Due to their obvious physiological effects on humans, several chemical components found in these plants offer therapeutic advantages [22,23].

Since ancient times, medicinal plants have played an essential role in human health, both personally and collectively [24,25]. Some chemical components in these plants have medical benefits because they have clear physiological effects on people [26,27]. This article focuses on quinoline alkaloids that were discovered to have pharmacological characteristics after being extracted from a few medicinal plants (Table 1).

Table 1: Chemical components of medicinal plants.

Various plant species include a group of natural substances known as quinoline alkaloids. They are distinguished by having a fused ring structure made up of two six-membered rings, one of which has an atom of nitrogen [28]. Quinoline alkaloids have a variety of biological effects, including as antibacterial, antimalarial, anticancer, and anti-inflammatory characteristics [29-36]. The diagnosis, treatment, and prevention of sickness all benefit greatly from plant-based medicines [37-42].

Conclusion

All of the compounds in this study were isolated from various medicinal plant parts, including the stem bark, fruits, leaves, stems, roots, and flowers. As a result, they demonstrated a variety of pharmacological actions on human health, including antioxidant, anti-inflammatory, anti-proliferative, antimicrobial, anti-mutagenic, anti-oangiogenic and neuroprotective actions. The pharmacological potentials of various plant extracts and several novel compounds derived from medicinal plants that have been demonstrated to be effective against a range of illnesses have been confirmed by docking studies.

Acknowledgement

The authors thank to lecturers of Chemistry Department, Federal University Gashua, Nigeria

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