Journal of Osteoporosis and Physical Activity
Open Access

Severe Injury-Induced Osteoporosis and Loach Skin Collagen Peptides Effect in Reducing Osteoporosis

Rahul Agarwal^{* *}Correspondence: Rahul Agarwal, Department of Pharmacology, Osmania University,Hyderabad, India, Email:

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Description

Feeling gives truth, a difficult ride; as of late, I was voyaging with a near, similarly matured family part, who fell and endured a femoral neck break. Surgical treatment is presently extraordinary, and all passed well; but what remained is the momentous straightforwardness of the event and the twisted complexity of its results, which sent me back to discover what had been learned approximately osteoporosis since the far off days of possess inquire about intrigued. But the look cleared out me baffled; in spite of much unused work, there was no characterizing component, and nothing likely to move forward on the negligible impact of work out, Ca, D3 and bisphosphonates. I was inquisitive almost the destiny of my ancient thought that osteoporosis, like skin maturing, was caused by misfortune of collagen and ought to be reversible by development hormone, maybe with androgen. My dissatisfaction on finding it had got no place, wasn’t marked parental pride, but that it had not been demonstrated to be off base. The plausibility that it had been missed instead of expelled [1].

The initial speculation emerged from a disentangling of the instrument of feeble purpura, which moreover clarified corticosteroid purpura. It was appeared that dermal changes with age (and corticosteroids) permitted burst of dermal vessels by shear constrain, and within the nonappearance of typical dermal confinement, the extravagated blood spread broadly (as did tentatively infused liquids), giving the injuries their characteristic appearance. This may as it was be caused by misfortune of the dermal collagen arrange; but, at the time, skin collagen was thought to be unaltered or increased3 with age. To resolve this, modern technique was created, and this appeared the misguided judgment emerged from the incorrect expression of collagen substance generally (to another constituent, or as a %), and when measured as an outright amount per skin surface range (employing a high-speed punch for exactness), all fell into put, and add up to skin collagen was appeared to diminish incrementally with age and corticosteroids. The misfortune is 1% per annum in men and ladies, in spite of the fact that female skin has less collagen within the sexist terms of collagen substance, female skin is a few 15 a long time ‘older’ than that of men. The misfortune isn't solar-induced, as was once accepted, and is comparable in all body areas.It is an inherent characteristic of collagen maturing and, thus, a comparable age misfortune with may well be anticipated in bone, which has the same overwhelming collagen sort as skin. The story at that point took on more than a dermatological intrigued, and it was a brief step to the idea that misfortune of collagen with age, happening in bone, fair as in skin, is the cause of osteoporosis within the elderly (and its sex distinction); moreover, with corticosteroid and ‘collagenolytic infections such as Ehlers-Danlos disorder, Marfan’s syndrome’[2].

Conclusion

Affirmation would require ‘studies of the supreme collagen substance of skin and bones’,4 but the straightforward to begin with test was the anticipated relationship between skin collagen and bone thickness. Add up to skin collagen substance was measured in patients with different skin, endocrine and hereditary conditions, and they all affirmed the relationship, and with the causal quality of a dose–response relationship for age and verbal corticosteroids. Patients with Cushing’s disorder had an incredibly diminished skin collagen and bone density; patients with acromegal had a gigantic increment in skin collagen (an impact missed when collagen was communicated as a rate) and their bones were thick; in differentiate, skin collagen substance was decreased in patients with hypopituitarism11 and their bones were diminished. The impact of androgen is clear from the comparative sex contrast in skin collagen and bone density, the expanded skin collagen in hirsute women in whom osteoporosis is less visit [3,4].

References

1. Shuster S, Scarborough H. Senile purpura. Quart J Med. 1961;30:33–44.
2. Sobel H, Gabay S, Wright ET. The influence of age on the hexosamine-collagen ratio of dermal biopsies from men. J Gerontol. 1958;13:128-131.
3. Shuster S, Black MM, MacVitie E. The influence of age and sex on skin thickness, skin collagen and density. Brit J Dermatol. 1975;93: 639–643.
4. Shuster, Raffle EJ, Bottoms E. Skin collagen in rheumatoid arthritis, and the effect of corticosteroids. Lancet. 1967;1:525–527.

References

1. Shuster S, Scarborough H. Senile purpura. Quart J Med. 1961;30:33–44.
2. Sobel H, Gabay S, Wright ET. The influence of age on the hexosamine-collagen ratio of dermal biopsies from men. J Gerontol. 1958;13:128-131.
3. Shuster S, Black MM, MacVitie E. The influence of age and sex on skin thickness, skin collagen and density. Brit J Dermatol. 1975;93: 639–643.
4. Shuster, Raffle EJ, Bottoms E. Skin collagen in rheumatoid arthritis, and the effect of corticosteroids. Lancet. 1967;1:525–527.