Journal of Clinical and Experimental Ophthalmology
Open Access

Study on Limbal Stem Cell Deficiency

Houda Bezza^1,2*, Zineb Algouti^1,2, Amine Mounsif^1,2, El Mehdi El-Filali², Salaheddine Bouabbadi², Kawtar Zoaui², Redouane Messaoudi² and Mohamed Kriet^{2 *}Correspondence: Houda Bezza, Department of Medicine and Pharmacology, University Cadi Ayyad, Marrakesh, Morocco, Email:

Author info »

Description

A 65-year-old patient presented with a pterygium with low visual acuity in the left eye. The clinical examination reveals that the patient's visual acuity was reducing to Counting Fingers (CF). The examination of the anterior segment showed a grade III bipolar pterygium with symblepharon.

An Optical Coherence Tomography (OCT) of the anterior segment showed a stromal infiltration of the pterygium. The surgical procedure consisted of a pterygium excision with the application of 5-Fluorouracil (5-FU) and a symplepharon release. A pterygium is a benign conjunctival fibro-vascular lesion. It’s encroaching progressively on the cornea and can become disabling [1]. The destruction of the limbus during the limbal stem cell deficiency involves a loss of its functions: The corneal epithelium can no longer regenerate by destruction of the limbal stem cell contingent and the limbic barrier can no longer contest against conjunctivalization [2,3] (Figure 1).

Figure 1:Bipolar pterygium-grade III with symblepharon.

References

1. Gueudry J, Majo F, Delcampe A, Muraine M. Panorama of Corneal Limbic Alterations. J Fr Ophtalmol. 2019;42(5): 517-528.

   [Crossref] [Google Scholar] [Pubmed]

2. Gatinel D, Hoang-Xuan T. Limbic Stem Cell Deficiency. J Fr Ophtalmol. 2000;23(7): 718-728.

   [Google Scholar]

3. Kocaba V, Damour O, Auxenfans C, Burillon C. Limbic Stem Cell Deficiency Treatment: A literature paper. J Fr Ophtalmol. 2016;39(9): 791-803.

   [Crossref] [Google Scholar] [Pubmed]