Cell & Developmental Biology
Open Access
ISSN: 2168-9296
+44 1478 350008
ISSN: 2168-9296
+44 1478 350008
Research Article - (2021)
Naturel and non-cytotoxic porous scaffolds were obtained with poly(vinyl alcohol) (PVA) and gelatin (GE) using electrospinning and freze/drying methods. Electrospinning scaffolds were produced as PVA/GE/GA crosslinked with glutaraldehyde (GA) and freeze/drying scaffolds crosslinked with genipin (GP) were divided into two groups as PVA/GE/GP5 and PVA/GE/GP8, respectively, according to their genipin ratio. In addition, the main biological significants of genipin is anti-cancer; antibacterial; anti-inflammatuar; antidiabetic; antithrombotic. Selenium is known to increase the proliferation of cells and for its antibacterial properties. The scaffolds were investigated in terms of pore morphology, swell ratio, biodegradation, and biocompatibility. The biocompatibility of the material was tested in vitro by MTT assay on days 1, 2, and 3 to test the cell viability of mouse 3T3 fibroblast cells. Although selenium has both antibacterial and cell proliferation effects, it has not yet been widely used in tissue engineering applications. In this study, for the first time synergistic effect of genipin and selenium was observed for 3T3 cells. This is significant because selenium with PVA/GE scaffolds can be a promising candidate for wound healing application, as it significantly increases cell viability on scaffolds. It is thought that the synergistic effect of selenium with genipin may be an important step in tissue engineering applications.
The article entitled “Synergistic Effect of Selenium and Genipin Triggers Viability of 3T3 Cells on PVA/Gelatin Scaffolds” has been accepted for publication in the Cell & Developmental Biology considering the statements provided in the article as personal opinion of the author which was found not having any conflict or biasness towards anything. As the article was a perspective one, information provided by the author was considered as an opinion to be expressed through publication. Publisher took decision to make the article online solely based on the reviewers suggestion which considered the article not but a personal opinion of the author. However, it is found that the author have some personal concerns and issues, therefore, being retracted from the journal.
Citation: Erdag D, Koc SN, Oksuzomer MF, Yalcintepe L (2001) Synergistic effect of selenium and genipin triggers viability of 3T3 cells on PVA/Gelatin scaffolds. Cell Dev Biol.10:236.
Received: 24-Aug-2021 Accepted: 07-Oct-2021 Published: 14-Oct-2021 , DOI: 10.35248/2168-9296.21.s1.236
Copyright: © 2021 Erdag D, et al. This is an open access article distributed under the term of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited