Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals

Federica Frezzato^1,2, Valentina Trimarco^1,2, Andrea Visentin^1,2, Veronica Martini^1,2, Filippo Severin^1,2, Monica Facco^1,2, Gianpietro Semenzato^1,2 and Livio Trentin^1,2*

¹Department of Medicine, Hematology and Clinical Immunology Unit, University of Padua, Italy

²Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

^*Corresponding Author: Livio Trentin, Department of Medicine, Hematology and Clinical Immunology Unit, University of Padua, Italy, Tel: 0039-049-821-2298, Fax: 0039-049-821-1970 Email: