A biological membrane, biomembrane or cell membrane is a selectively permeable membrane that separates cell from the external environment or creates intracellular compartments.
Biological membranes allow life as we know it to exist. They form cells and enable separation between the inside and outside of an organism, controlling by means of their selective permeability which substances enter and leave. By allowing gradients of ions to be created across them, membranes also enable living organisms to generate energy. In addition, they control the flow of messages between cells by sending, receiving and processing information in the form of chemical and electrical signals. This essay summarizes the structure and function of membranes and the proteins within them, and describes their role in trafficking and transport, and their involvement in health and disease. Techniques for studying membranes are also discussed.
Biological membranes consist of a double sheet (known as a bilayer) of lipid molecules. This structure is generally referred to as the phospholipid bilayer. In addition to the various types of lipids that occur in biological membranes, membrane proteins and sugars are also key components of the structure. Membrane proteins play a vital role in biological membranes, as they help to maintain the structural integrity, organization and flow of material through membranes. Sugars are found on one side of the bilayer only, and are attached by covalent bonds to some lipids and proteins.All membrane lipids are amphipathic—that is, they contain both a hydrophilic (water-loving) region and a hydrophobic (water-hating) region. Thus the most favourable environment for the hydrophilic head is an aqueous one, whereas the hydrophobic tail is more stable in a lipid environment. The amphipathic nature of membrane lipids means that they naturally form bilayers in which the hydrophilic heads point outward towards the aqueous environment and the hydrophobic tails point inward towards each other.