Endocrinology & Metabolic Syndrome
Open Access

Leiomyomas Health Journals

Leiomyomas are benign tumors composed of smooth muscle cells and varying amounts of fibrous connective tissue. These synonymously termed as fibromyomas, fibroids, or myomas are the commonly encountered benign uterine neoplasms in women of reproductive age group accounting for 5-20%.Complex interactions of sex steroid hormones and local growth hormones with mutations in the normal myometrium are being considered as the possible etiology. Leiomyomas need hormonal milieu for their growth and maintenance as evidenced by the molecular studies that they exhibit more estrogen receptors than normal myometrium.Unopposed estrogenic stimulation manifests as leiomyomas undergoing secondary changes and endometrial proliferation or hyperplasia.However, there are very few studies to elaborate on these pathological changes; hence, in this context the present study was taken up.