Staphage lysate is a bacterin prepared by bacteriophage lysis of human-origin Staphylococcus aureus. Staphage lysate has been given as adjunct therapy to dogs with idiopathic recurrent superficial pyoderma but has not been extensively evaluated in cases of deep pyoderma. Treatment has been shown to be beneficial in up to 70% of cases of superficial pyoderma. The objective of administration is to enhance the host immune response to Staphylococcus spp; however, repeated injection of staphage lysate does not lead to elevated levels of serum antibody specific for S. intermedius antigens in dogs with superficial pyoderma.
Formulations and dose rates
One suggested dosage regimen is to administer staphage lysate, concurrently with appropriate antibiotics, at 0.5 mL twice weekly for 6 weeks by SC injection. Following cessation of antibiotics, staphage lysate monotherapy is continued for a further 4–8 weeks
In order to maintain remission, intermittent administration of staphage lysate may be required thereafter