Smallpox was an infectious disease caused by one of two virus variants, Variola major and Variola minor.The last naturally occurring case was diagnosed in October 1977, and the World Health Organization certified the ecumenical eradication of the disease in 1980.The risk of death following contracting the disease was about 30%, with higher rates among babies.Often those who survived had extensive scarring of their skin, and some were left blind.The initial symptoms of the disease included pyrexia and regurgitating.This was followed by formation of sores in the mouth and a skin rash.Over a number of days the skin rash turned into characteristic fluid-filled bumps with a dent in the center.The bumps then scabbed over and fell off, leaving scars.The disease was spread between people or via contaminated objects.Prevention was primarily by the smallpox vaccine.Once the disease had developed, certain antiviral medication may have availed.The inception of smallpox is unknown.The earliest evidence of the disease dates to the 3rd century BCE in Egyptian mummies.The disease historically occurred in outbreaks. In 18th-century Europe, it is estimated 400,000 people per year died from the disease, and one-third of the cases resulted in optical incapacitation.These deaths included six monarchs.Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its subsistence.As recently as 1967, 15 million cases occurred a year. To increment the overtness and facilitate of avail of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving accommodations. Indexing provides facile access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are paramount for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more paramount than those with lower ones. Indexing provides facile access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, pertinent and reliable information predicated on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated utilizing citations not only from research articles but adscititiously review articles (which incline to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and endeavor to increment their number expeditiously. Impact factor plays a major role for the particular journal.