Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Hamdi TEMEL, Mustafa Abdullah YILMAZ, Ibrahim Demirtas and Abdulselam Ertas
Dicle University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry Diyarbak�±r, TURKEY
Dicle University Science and Technology Application and Research Center, Diyarbak�±r, TURKEY
Department of Chemistry, Faculty of Science
Posters & Accepted Abstracts: J Develop Drugs
Being the most indigenious economic plants of Anatolia, Achillea genus is widespread all over the world and in literature its species have been investigated to possess several biological activities including cytotoxicty. In the present study, cytotoxic activities of chloroform-methanol extracts (1:1) of underground and overground parts of four Achillea species (A. monocephala, A. nobilis, A. goniocephala and A. sintenisii ) on HeLa (Human Cervical Carcinoma Cell Line) cell lines at concentrations 50, 100 and 250 �¼g/mL were investigated. The cytotoxic activities were tested using a real-time analyzer (xCELLigence). The xCELLigence system was used with the disposable E-plate 96 for the measurements of solvent extracts, controls and medium. The impedance difference based measurements were caused by the cells attached to the E-Plate 96. Fortunately, all of the extracts showed very high cytotoxic activity depending on the concentration. The lower the extract concentration the lower the cytotoxic activity. The highest cytotoxic activities were shown by underground extracts of A. monocephala (-0.0142) and A. goniocephala (-0.0119).
Hamdi Temel is working as a full Professor since 2008 at Dicle University, Diyarbakir, Turkey. He is dean of the Faculty of Pharmacy in Dicle University. His research areas are synthesis and characterization of biologically active compounds, antioxidant studies etc. He has published more than 90 papers in reputed journals.
Email: htemelh@hotmail.com