Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
+44 1300 500008
ISSN: 2157-7064
+44 1300 500008
Ksenija Kumric
University of Belgrade, Serbia
Posters & Accepted Abstracts: J Chromatogr Sep Tech
Long-lived radionuclide 90Sr is an ideal source of carrier-free 90Y (T1/2=64.1 h, E�²max=2.3 MeV), which has suitable radionuclidic characteristics for the application in endoradiotherapy of malignant tumors. Separation of Y(III) from Sr(II) with 15% (v/v) di(2-ethylhexyl)phosphoric acid (DEHPA) in dodecane was performed using the hollow fiber supported liquid membrane (SLM) contactor operated in a recirculation mode. The influence of various experimental parameters (contact time, donor pH, DEHPA concentration, donor and acceptor flow rates) on the mass transfer rate of Y(III) and the separation effects in the applied system was investigated. The steady-state was established after about 5-6 hours of operation. A yield of Y(III) in the acceptor phase increased as the flow rate of both aqueous phases increased and reached 72% at the acceptor flow rate of 1.9 cm3min-1 and the donor flow rate of 4.7 cm3min-1. However, a breakthrough of Sr(II) through the SLM also increased with increasing the acceptor flow rate, so that flow conditions must be optimized to find a balance between the requirement for a high yield of Y(III) in the acceptor phase and a low breakthrough of Sr(II) through SLM. Hollow fiber SLM contactor operated in a recirculation mode under optimized flow conditions could be used for the development of 90Sr-90Y generator system and milking of 90Y in the form suitable for direct complexation with various chelating agents and preparation of 90Y-radiopharmaceuticals.
Email: kkumric@vin.bg.ac.rs