Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Yiming Tian
The First Hospital of Qinhuangdao, China
Posters & Accepted Abstracts: J Clin Exp Ophthalmol
Zoledronic acid induced uveitis (ZAIU) is acute bilateral or unilateral uveitis after administration of zoledronic acid, usually presented with eye irritation, periorbital swelling, blurred vision and diplopia. It is rare but severe; only 15 cases have been reported since 2005, including our case report. Recently, ZAIU is starting to be taken as part of acute-phase reaction (APR) after bisphosphonate dispensing due to the same time frame they occurred in. As a result, it seems more unfrequent to develop uveitis after oral bisphosphonate tolerance, the same as APR. Interestingly, we reported a 63 year old female patient suffered uveitis soon after intravenous zoledronic acid while tolerated a two year treatment of oral alendronate in postmenopausal osteoporosis. All the ocular symptoms presented and a diagnosis of bilateral acute uveitis and right macula edema was made after adjudicated by an ophthalmologist. The ocular symptoms were not improved until administration of topical and oral steroids. Complete resolution was achieved finally. No re-challenge and no recurrence in 6 months follow-up. This is the first report of zoledronic acid induced uveitis with macula edema after long-term alendronate tolerance. In conclusion, prior oral alendronate may not prevent ZAIU entirely, steroids are usually necessary in the treatment.
Email: Yiming_Tian@foxmail.com