Journal of Clinical & Experimental Dermatology Research
Open Access

A novel efficient and safe treatment for atopic dermatitis: Topical superoxide dismutase (SOD)

9^th World Dermatology & Pediatric Dermatology Congress

October 10-11, 2016 Manchester, UK

Christian Diehl

Marconi University, Italy

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

The role of oxidative stress in the occurrence and maintenance of atopic dermatitis (AD) is more and more pointed out. The levels of inflammatory cytokines produced by Th2 (IL-4, IL-5, IL-13), by Th17 (IL-6, IL-17, IL-22) and by macrophages and epithelial cells (IL-1�², TNF-�±, IL-6) are all increased in AD. The release of all these cytokines is under strong influence of ROS and oxidative stress is marked in AD. Superoxide dismutase features a strong antioxidant able to scavenge superoxide radicals. It was demonstrated that superoxide dismutase 3 controls adaptive immune responses, but also inhibits the immune response of Th2 cells and reduces the expression of IL-4, IL-6, IL-8 and IL-13. It also reduces the levels of NO, NOS and iNOS whose increase induces pruritus. For this reason, it was tested in children with AD in topical application, giving excellent results with very good tolerance. The results of these trials are presented here, which make topical SOD a promising alternative to topical steroids in the management of AD in children.

Biography :

Email: chdiehl@hotmail.com