Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Bansal Reena, Chandra and Subhash
Accepted Abstracts: Pediatr Therapeut
Context: Cervical priming using prostaglandins prior to surgical evacuation reduces the risks of cervical injury. Objective: To compare the effi cacy of intramuscular Prostodin and intravaginal Misoprostol in cervical dilatation for fi rst trimester termination of pregnancy or missed abortion. Design, Setting, and Participants: A randomized controlled trail was conducted between November 2008 to August 2010 at a tertiary care and academic hospital in Southern India. One hundred adult pregnant women up to 12 weeks of gestation, aged 18 to 35 years, opted for medical termination of pregnancy or presented with missed abortion. Fift y were randomized to receive intramuscular Prostodin and rest 50 intravaginal Misoprostol. Intervention: Aft er randomization to one or another group, patients received deep intramuscular injection of 1 ml Prostodin (equivalent of 250microgram of carboprost) or 600 microgram of Misoprostol intravaginally. Primary outcome measure: Amount of cervical dilatation achieved. Cervical dilatation was measured aft er 4 hours of drug administration using Hegar?s dilator. Results: Th ere was no signifi cant diff erence in distribution of age (p=0.832), parity (p=0.537), and proportion of missed abortion and elective medical termination of pregnancy (p=0.368), between two groups. Mean (standard deviation) cervical dilatation in Misoprostol group was signifi cant higher and protodin group, 9.2 (3.1) and 7.7 (2.1) cm, respectively (p=0.005). Th e mean diff erence (std. error) between two groups was 1.54 (0.53) cm. Mean (SD) amount of blood loss in Misoprostol group was 58.8 (20.1) ml which was signifi cantly higher than Prostodin group, 30 (11.9) ml (p <0.001). Conclusion: Intravaginal Misoprostol use gives better cervical dilatation when compared to intramuscular Prostodin.