Journal of Proteomics & Bioinformatics
Open Access

Acetylcholinesterase inhibiting activity of compounds isolated from bauhinia rufescens

Joint Event on 9^th World Biomarkers Congress & 20^th International Conference on Pharmaceutical Biotechnology

December 07-09, 2017 | Madrid, Spain

Aminu Muhammad and Hasnah Mohd Sirat

Bayero University Kano, Nigeria
Universiti Teknologi Malaysia, Malaysia

Posters & Accepted Abstracts: J Proteomics Bioinform

Abstract :

This study has tested the in vitro anti-acetylcholinesterase activity of compounds isolated from the stem bark of Bauhinia rufescens by employing TLC bioautographic and Ellmanâ��s spectrophotometric methods. Among the compounds oxepin (IC50, 516.63 �¼M), seqouyitol (IC50, 463.77 �¼M) and �±-amyrin acetate (IC50, 832.80 �¼M) which exhibited a significant acetylcholinesterase inhibitory activity in comparison with a positive control, the galantamine hydrobromide (IC50, 2.92 �¼M). The phytochemicals isolated from the stem bark of B. rufescens had demonstrated a potent anti-cholinesterase inhibition.