Biochemistry & Pharmacology: Open Access
Open Access

Administration of 1-deoxynojirimycin attenuates hypothalamic endoplasmic reticulum stress and regulates food intake and body weight in mice with high-fat diet-induced obesity

Joint Event on 10^th World Congress on Pharmacology & 6^th International Conference and Exhibition on Advances in Chromatography & HPLC Techniques

August 02-03, 2018 | Barcelona, Spain

Tae-Won Goo, Eun-Young Yun and Seung-Won Park

Dongguk University College of Medicine, Republic of Korea
Sejong University, Republic of Korea
Catholic University, Republic of Korea

Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)

Abstract :

The �±-glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression. We conclude that DNJ may reduce obesity by moderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS).