ISSN: 2376-0419
+44 1300 500008
Katarzyna Grzybowska, K Chmie, J Knapik, A Grzybowski and M Paluch
University of Silesia, Poland
Silesian Center for Education and Interdisciplinary Research, Poland
Scientific Tracks Abstracts: J Pharma Care Health Sys
A transformation of poorly water-soluble crystalline pharmaceuticals to the amorphous form is one of the most promising
strategies to improve their oral bioavailability. Unfortunately, the amorphous drugs are usually thermodynamically
unstable and quickly return to their crystalline form. A very promising way to enhance the physical stability of amorphous
drugs is to prepare amorphous compositions of APIs with certain excipients which can be characterized by significantly
different molecular weights, such as polymers, acetate saccharides and other APIs. We examine the effect of adding large
molecular weight polymer polyvinylpyrrolidone (PVP K30) and the small molecular weight excipient octaacetylmaltose
(acMAL) on the tendency to recrystallization of the amorphous celecoxib (CEL) in the amorphous solid dispersions: CEL-PVP
and CEL-acMAL. We found that acMAL is a better inhibitor of recrystallization of amorphous CEL than PVP K30 deep in the
glassy state (T
Katarzyna Grzybowska has received her PhD degree in Physics at the University of Silesia in 2008. In 2012, she has completed a four-year Post doctorate in the research project "From Study of Molecular Dynamics in Amorphous Medicines at Ambient and Elevated Pressure is Novel Applications in Pharmacy" in the Institute of Physics at the University of Silesia. She is a co-author of more than 60 publications in the international peer reviewed journals from ISI list and two patents.