Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Sahar A El-Masry, Mona M El-Ganzoury, Rania A El-Farrash, Mona Anwar and Rasha Z Abd Ellatife
National Research Centre, Egypt
Ain Shams University, Egypt
Posters & Accepted Abstracts: Clin Pediatr
Background: Diabetes is recognized as a particular threat to pregnant women and their neonates. Maternal concentrations of
insulin-like growth factor-I (IGF-I) and its binding protein-1 (IGFBP-1) have influence on fetal growth.
Objective: To estimate the association between the anthropometric measurements; which evaluate intrauterine fetal growth
and biochemical growth factors; IGF-I and IGBP-1 among IDMs, in attempt to predict them.
Methods: Cross-sectional study carried out on 69 full term IDMs admitted to neonatal intensive care units, Ain Shams
University Hospitals. Clinical examination including anthropometric measurements; birth weight, length, head circumference
and mid-arm circumference and placental weight. Laboratory investigations included maternal HbA1c and cord blood IGF-I
and IGBP-1. They were classified into three groups: 20 small for gestational age (SGA), 25 appropriate for gestational age
(AGA) and 24 large for gestational age (LGA).
Results: Most of SGA neonates were born to mothers with type I diabetes, while most of AGA and LGA were born to mothers
with gestational diabetes. According to maternal HbA1c, SGA and LGA neonates were born from metabolically uncontrolled
mothers while AGA neonates were born to well-controlled diabetic mothers. Anthropometric measurements had significant
positive correlations with IGF-I and negative correlations with IGFBP-1. Three equations were performed to predict IGF-I and
IGFBP-1 from body weight, length or head circumference.
Conclusions: Good control of diabetes during pregnancy is essential to improve fetal growth. There is an opposing effect of
cord blood IGF-I and IGFBP-1 on anthropometric measurements. IGF-I and IGFBP-1could be predicted from anthropometry.
E-mail: masrysa@yahoo.com