Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Prapaipat Klungsupya
Thailand Institute of Scientific and Technological Research, Thailand
Posters & Accepted Abstracts: J Develop Drugs
Ageing is a natural process which is accompanied by normal physical, chemical, and biological changes in the body. The world population is rapidly ageing. By 2050, the number of the people aged 60 and older will rise to about 22%. Therefore, anti-ageing products are of great demand for consumers of this group. Our latest study was carried to search and develop new anti-ageing products containing natural anti-oxidant substances from seeds of grape Vitis vinifera cv. Ribier grown in Thailand. It has been known that oligomeric proanthocyanidins (OPCs) are the most abundant of flavonoids found in the grape seeds, especially the red grapes (Vitis vinifera). A large number of publications have proven that OPCs possess the powerful anti-oxidant property and that have been suggested to reduce the risk of many oxidative-mediated diseases including cardiovascular disease, Alzheimer��?s disease and cancers. The extensive research both in vitro and in vivo studies shown OPCs can act as anti-carcinogenic agent by activities include reduced proliferation, increased apoptosis, cell cycle arrest in tumor cells. By 3 year-study, we could prove various pharmacological activities of the OPCs in Thai grape seed extracts including DNA-protective activity against UV and free radicals, enzymatic and non-enzymatic anti-oxidant property, anti-mutagenic and anti-inflammatory activities. Following safety determinations at cellular level, Thai OPCs was used as a health promotor in development of dietary supplement capsules. Also, for a beauty reason, it was used as natural active ingredient in formulation of two nanocosmeceutical products including anti-ageing day- and night creams. These products successfully passed the clinical studies and are ready for the commercialization.
Email: prapaipatk@yahoo.co.uk