Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Saharnaz Rakizadeh, Azadeh Izadyari, Yones kafi and Masood Sahraiy
Posters: J Clin Exp Dermatol Res
Nowadays more than half of the population in the world is suffering from dandruff, followed by hair loss, irritation, white flakes and itchy scalps. The mentioned disorder is mainly caused by oil dependent fungi due to exceeding sebum and di-hydrotestosterone (DHT). DHT stimulates sebaceous glands to produce excessive sebum; Therefor, fungi such as Malasseziasecrets lipaseto cleavesebaceous triglycerides into free fatty acids for consumption, also increase amount of unsaturated fats to penetrate into the epidermis and induce irritation and flaking. In Ceritaanti dandruff Shampoo (PZ+), Zincpyrrolidone carboxylic acid (Zinc-PCA) 1% and piroctoneolamine (PO) 1%, are combined with herbal extracts. Zinc-PCA and PO, decrease unwanted sebum secretion and inhibit resistant dandruff. In this experiment, 30 sufferers (above 12) with highly resistant dandruff were closely observed. After four weeks, results revealed dandruff and related hair loss inhibition, followed by itching and inflammatory remove. In PZ + , herbal extracts such as Punicagranatum has effective antidandruff properties due to punicalagin, also β-sitosterolandellagic acid are anti-itching and anti-inflammatory compounds. On the other hand, Cineole and α-pinene in Rosemarinusofficinalis reduce fatty acid peroxidation, results to fungi growth inhibition in pH=5-6. Interestingly, α-bisabolol andluteolin as anti-inflammations, inhibit cox-1, cox-2 and prostaglandin synthesis, in addition, Azulene and coumarin inhibit histamine release. Ursolic acidin Urticadioica and mentolin Menthapiperita respectively, inhibits 5-α-reductas and promotes blood flow to nourish follicles. To conclude, combination of Zinc-PCA and PO augment resistant dandruff inhibition and herbal extracts reduce chemical side effects furthermore increase therapeutic effectiveness.
Saharnaz Rakizadeh has completed her Master in and graduated from University of Tehran, Iran, in 2012. Her thesis was on researching about medicinal herbal extracts(microbial effects, phytochemistry, pharmaceutical affairs and ...) She is researcher and manager of Science Department in a big Pharmaceutical research company- Pars AzmayeTeb (Cerita ) - She has many conferences and presents in scientific meetings.