Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-77-2385-9429
ISSN: 2167-0501
+44-77-2385-9429
Soumeya Krimat and Aicha Kesouri
ENS, Kouba, Algeria
Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)
Lavandula antineae Maire is an endemic medicinal plant of Algeria which is traditionally used as a popular remedy against chills, bruises, edema and rheumatism1. The objective of this study is to evaluate the anti-inflammatory activity of the hydromethanolic extract of the aerial parts of Lavandula antineae for the first time using two models of inflammation: carrageenan-induced paw edema and ear edema induced by croton oil 2,3. In the first model, the pretreatment of mice, by the plant extract, inhibited significantly the development of edema in a dose-dependent manner, with kinetics of action similar to that of aspirin (reference product) . In addition, the local application of 2 mg of extract induced a very significant reduction (P<0.05) of ear edema compared to the control group with a inhibition of 74.67 %. These results demonstrate that the Lavandula antineae Maire species has an important anti-inflammatory activity, thus justifying its folkloric use as a remedy for various inflammatory disorders.