Journal of Cell Science & Therapy
Open Access

Apoptotic signaling proteins as the factors control neural differentiation

2^nd World Congress on Cell Science & Stem Cell Research

November 12-14, 2012 Hilton San Antonio Airport, USA

Margarita Glazova and Elena Chernigovskaya

Scientific Tracks Abstracts: J Cell Sci Ther

Abstract :

A poptotic signaling proteins play the critical role during development of CNS. These proteins mainly control the size of developing neuronal populations. However, accumulating data demonstrated that apoptosis-related proteins participate in the regulation of ESC differentiation. For example, cell death-relevant proteins are functionally involved in differentiation of a wide range of cell types. We analyzed development of hypothalamus nuclei in Bcl-2 and p53 knockout mice. Obtained data demonstrated that Bcl-2 and p53 deficienciesaffected not only on the functional activity of neuroendocrine cells of hypothalamus, but also differentially changed the cell?s populations. These observation let us supposed that apoptosis-relevant proteins may participate in the regulation of differentiation of neuroendocrine cells of hypothalamus or to be involved in proliferation and/or differentiation of neural progenitor cells (NPC). We have studied differentiation/proliferation of neural progenitorsisolated from hippocampus of new-born mice. Inhibition of Bcl-2 with HA14-1 during differentiation initiated glia formation, while pifithrin- alpha treatments (inhibitor of p53 activity) led to inhibition of neural differentiation but upregulated of NPC self-renewal. Thus, our data demonstrated that apoptosis signaling proteins may regulate the mechanisms of NPC differentiation.This work was supported by grants from Russian Foundation for Fundamental Research (RFBR 10-04-00127-a, and RFBR 11-04-00648-a)

Biography :

Glazova received the Ph.D. (1997) from Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Science and postdoctoral fellow of Adj. Professor P.Koskinen, Turku Centre for Biotechnology, University of Turku/ÅboAkademi, Finland (2001-2003). Then, she was a Research Associate of Prof.A.K.Murashov, East Carolina University Brody School of Medicine, Department of Physiology, Greenville NC, USA (2004-2006).); and now she is Senior Researcher at the Laboratory of Comparative Somnology and Neuroendocrinology, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St.Petersburg, Russia. She has published more than 30 articles in peer-reviewed scientific journals