Pancreatic Disorders & Therapy
Open Access

Are incretins promoters or initiators of pancreatic cancer?

2^nd Intenational Conference on Pancreatic Disorders & Treatment

September 13-14, 2017 Dallas, USA

Parviz M Pour

University of Nebraska Medical Center, USA

Posters & Accepted Abstracts: Pancreat Disord Ther

Abstract :

Recently, striking abnormalities in the insulin-ductuar cells of pancreas were reported in Type-2 diabetic patients treated with GLP-1-1 analog. Our studies revealed that these alterations were almost identical to the early neoplastic changes that occur in the hamster pancreatic cancer model. To confirm these similarities, we examined the pancreas of a Type-2 diabetic patient, who developed pancreatic cancer a year after the treatment with GLP-1 analogs. As in the hamster model, there were multifocal proliferation of insulin-ductular cells with atria and patterns consistent with in-situ carcinomas. The relevance of these findings and possible biological pathways will be discussed.