Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Befikadu Taye Tadesse
Accepted Abstracts: J Clin Cell Immunol
Eucalyptus oil, an essential oil isolated from Eucalyptus leaves, was examined for its possible influence on LPS and Klebsilla pneumonia induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumonia (K.P, density, ≥6×108 CFU/mL). The test compound, Eucalyptus oil (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K.P and lasted for 4 weeks. Eucalyptus oil significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and significantly decreased bronchiolitis, alveolar destruction, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone acetate also significantly attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found in emphysema. Eucalyptus oil exerts its antioxidant activities and decreased the elevated MDA levels and increased the level of SOD in lung tissues. These findings suggest Eucalyptus oil as an active controller of airway inflammatory responses and oxidant stress in COPD rats. Further studies are in progress in order to elucidate the mechanisms. Our results provide evidence that Eucalyptus oil might have its potential to be a proper candidate drug in the treatment of COPD .
Chunzhen Zhao, PhD is a Lecturer, Department of Pharmacology, 7166 Baotong Street, Weifang Medical University, Weifang 261053, China. He graduated from Zhejiang University, China and earned a Doctor?s Degree in Pharmacology from college of Medicine in 2011. He is member of Chinese Pharmacological Society, Member of Pharmacological Society of Shandong Province.