Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Maha AlMolaiki, Rami Bustami and Husam I Ardah
King Abdulaziz Medical City-Central Region, Saudi Arabia
King Saud University, Saudi Arabia
King Abdullah International Medical Research Center, Saudi Arabia
King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia
King Abdulaziz Medical City-Central Region, Saudi Arabia
Scientific Tracks Abstracts: J Pharma Care Health Sys
Background: Stroke is a rapid loss of brain function due to disruption of blood supply to the brain and a major cause of mortality and morbidity worldwide. In Saudi Arabia the incidence of ischemic stroke is 69%. Risk factors are: hypertension, diabetes mellitus, smoking, dyslipidemia. Proton pump inhibitors (PPIs) one of the world�??s most frequently prescribed medications contributed to many adverse effects. Retrospective study found a significant increase in risk of new onset ischemic stroke in the PPIs users. Prospective cohort study found no association. Aim: assess the likelihood of developing new onset ischemic stroke among patients who were using PPIs for 6 months or more versus patients who were not using PPIs. Method: Case-control study at King Abdulaziz Medical City central region, from January2016 to January2017.Sample size calculations based on probability type I error of 0.05,80%power, estimated to be 400[200 ischemic stroke(cases) and 200 nonischemic stroke(controls)]. Each group obtained by simple random sampling, medications reviewed if patients were using PPIs. The association between PPIs use, demographic data, clinical factors and development of ischemic stroke evaluated by using Odds Ratio (OR) and 95%confidence interval (CI). Continuous data expressed as mean ±SD. Categorical data analyzed using the Chi-square test. Result: 128 patients met the inclusion criteria.64 patients with 47 on PPIs had new onset ischemic stroke (meanage69.14±11.57, 53.13%were male), 64 patients with 39 on PPIs without ischemic stroke (mean age 60.88±12.49, 54.69%were female). Primary endpoint: there was insignificant association between patients with previous exposure to PPIs and ischemic stroke (Odds Ratio (OR) 0.396; 95% (CI) 0.111�??1.415),In comparison to the retrospective study. For secondary endpoint: the incidence of ischemic stroke was insignificant between patients who used different doses, 20mg orally daily in ischemic and non-ischemic stroke (29.79%Vs.48.72%, respectively), and 40mg orally daily in ischemic stroke and non-ischemic stroke (70.21%Vs.51.28%, respectively), P=0.0723. Conclusion: Association between PPIs use with different doses prior the occurrence of new onset ischemic stroke is insignificant, after accounting PPIs indications, several factors contributed to the risk of ischemic stroke.
Maha AlMolaiki has completed her PharmD from King Saud University and has worked assisting as Patient Cares, both in outpatient and inpatient at King Abdulaziz Medical City-Central region. She is currently a Pharma Resident at Pharmacy Residency at King Abdulaziz Medical City-Central Region.
E-mail: Almolaikima@ngha.med.sa