Transcriptomics: Open Access
Open Access
ISSN: 2329-8936
ISSN: 2329-8936
Sushmavenkat
Accepted Abstracts: Transcriptomics
Weak immunity surveillance has been the main reason for progression and rapid development of various cancers reported. Though the associations between cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene 49 G/A polymorphism and breast cancer has been widely assessed, a definitive conclusion remains elusive and still focused by scientific community. The present study aims to evaluate the potential influences of CTLA-4 gene polymorphisms on breast cancer risk in invasive ductal carcinoma of tumor tissue and healthy tissues. Tumor tissue of forty confirmed breast cancer patients was included as cases. The same forty patientsâ?? adjacent non-tumor tissue samples were considered as controls. The prevalence of AA, GG and AG genotypes was 42.1%, 15.8.2% and 42.8% in the tumor tissue and non-tumor tissues respectively. Individuals containing tumor and non-tumor tissue samples showed significance in breast cancer in which homozygous A/A and heterozygote G/A found to be more significant than G/G genotype.The study confirmed that the presence of at least one â??Aâ?? allele may increase the risk of breast cancer when compared to the presence of â??Gâ?? allele in same patient.
Sushmavenkat did her bachelor degree (2007) from Genetics as combination subjects, followed by Masters in Genetics (2009) and joined PhD in 2011 in Department of Genetics under the supervision of Prof. K. Rudrama Devi. Her research interest mainly involves work on woman related cancers, and thus she chose the topic of Breast Cancer. She is associated with Indo American Cancer Hospitals for specimen collection and collected about 150 paired tissue specimens for the research work. After PhD she is planning to go for Post Doctorate studies. Two of her manuscripts have been accepted in international journals. She has been working on 4 different gene polymorphisms and doing the correlation study with each impact on Breast Cancer.