Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Sujit Kumar Jha, Gautam N, Jayan A, Dubey R K, Jha A C, Sah S, Sharma B K, Bohara S, Shah A and Nepal M
Deuri Parabaha Primary Health Centre, Nepal
Universal College of Medical Sciences, Nepal
Posters & Accepted Abstracts: Thyroid Disorders Ther
Background: HypoThyroidism is the most common cause of secondary dyslipidemia. It is therefore necessary to assess Thyroid function test before starting hypolipidemic drugs. The hypoThyroidism is more prone to have cardiovascular and associated problems. These risk factors are cumbersome to control if not detected earlier and manifested later with severe clinical constellations. Our study assesses the frequency and spectrum of dyslipidemia in various types of Thyroidal illness in the population residing in south western part of Nepal. Methods: This is a cross sectional study carried out in suspected Thyroid disorder patients (n=276) and categorized as euThyroidism (n=55), subclinical hypoThyroidism (n=89), primary hypoThyroidism (n=122) and primary hyperThyroidism (n=10) patients and to see the association with lipid profiles in the Department of Biochemistry, Universal College of Medical Sciences Teaching Hospital, Bhairahawa Nepal. Serum fT3/fT4 and TSH estimations were carried out by competitive ELISA method and sandwich double antibody ELISA method respectively using commercially supplied reagents (Human, Germany). The criteria for dyslipidemia were obtained by National Cholesterol Education Expert Panel/Adult Treatment Protocol III (NCEP/ATPIII). Results: Out of all cases, dyslipidemia was mostly associated with primary hypoThyroidism (55.07%) followed by subclinical hypoThyroidism (38.04%) than euThyroid (5.79%) and primary hyperThyroidism (3.62%) respectively. Out of all cases, the spectrum of dyslipidemia was mostly observed for decreased HDL (18.5%) followed by increased TG (10.1%). Moreover, it significantly differ in relation to HDL (p=0.009) and TG/HDL (p=0.02) where as non significant as compared to other lipid profile in different groups. Conclusions: Our study revealed the close association of Thyroidal illness with dyslipidemia with increased TG, low HDL and increased TG/HDL. The increased TG/HDL and/or non-HDL/HDL could be better indicator than single lipid abnormality, which needs to be ascertained prospectively in large population.