Pediatrics & Therapeutics
Open Access

Associations between preterm birth and maternal-newborn ABO Blood Phenotype Pair: A retrospective case-control study

International Conference on Pediatrics & Gynecology

6-8 December 2011 Philadelphia Airport Marriott, USA

Sameer Al-Abdi

Department of Pediatrics, King Abdulaziz Hospital, Saudi Arabia

Posters & Accepted Abstracts: Pediatr Therapeut

Abstract :

Background: Maternal-fetal ABO incompatibility is associated with spontaneous abortion. Spontaneous abortion puts subsequent pregnancies at risk of preterm birth. Our aim to study whether preterm birth is associated with maternal-newborn ABO blood phenotype pairs.

Study design: Th is was a 1:2 retrospective case-control study. A total of 1,089 consecutive live singleton preterm births (<37 weeks) between August 2005 and May 2011 formed the case group. A total of 2,232 consecutive live singleton term births (≥37 weeks) between May 2008 and April 2009 formed the control group. We extracted data on the mothers and their newborns from our neonatal electronic database and delivery room log book. We extracted ABO blood phenotypes using Cerner Lab Information System Soft ware. We used a Chi square test to study the association between preterm birth and 14 maternalnewborn ABO pairs. We used maternal-newborn O-O pair as the reference group. We used a binary logistic regression analysis to adjust for nine risk factors for preterm birth.

Results: Preterm birth was associated with only maternal-newborn pairs B-A (odds ratio: 2.22, 95% confi dence interval: 1.20- 4.11, P=0.01) and AB-B (odds ratio: 1.80, 95% confi dence interval: 1.04-3.12, P=0.03). Both associations remained signifi cant in the regression analysis.

Conclusion: Preterm birth is associated with two maternal-newborn ABO pairs, B-A and AB-B. Th ese fi ndings require further confi rmatory study.