Journal of Developing Drugs
Open Access

Biological effects of modified curcumin on cancer cells and Leishmania Parasites

Joint Event on 14^th International Conference on Generic Drugs and Biosimilars & 9^th Global Experts Meeting on Neuropharmacology

November 15-16, 2018 | Berlin, Germany

Adel Hidmi, Zaidoun Salah, Sharehan Ariqat and Abedelmajeed Nasereddin

Al-Quds University, Palestine
Birzeit University, Palestine

Scientific Tracks Abstracts: J Dev Drugs

Abstract :

Curcumin is the active ingredient in the turmeric rhizomes. The diarylheptanoid structure of curcumin has been found in recent studies to possess potential biological activities against a wide range of numerous human diseases. Despite this potential, curcumin has two main disadvantages associated with its structure: poor stability and low bioavailability. Also, Nitric Oxide (NO) holds a great potential for NO-based treatments for a wide variety of diseases. To check the combined effect of Curcumin and NO, we synthesized a Nitro-Curcumin hybrid through nitrate esterification reaction at the keto-enol position of curcumin and simultaneous aromatic nitration. In the current study, the anti-Cancer as well as anti-Leishmanial activities of modified curcumin (NO-curcumin) were observed and compared to those of unmodified curcumin. Under in vitro conditions, the modified NO-curcumin was found to possess stronger activity than the original structure. Exhibiting reducing cell proliferation, increasing cell death and lowering IC50. Moreover, we found that NO-curcumin has no cytotoxic effects on normal cells. Therefore, the modified natural compound (NO-curcumin) may serve as a promising alternative to the currently used drugs and continues to be researched in further related studies. Recent Publications: 1. Jantarat C (2013). Bioavailability enhancement techniques of herbal medicine: a case example of curcumin. Int J Pharmacy Pharm Sci 5: 493�?? 500. 2. 2. Kim, K.C., Lee, C (2010) Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species. Korean J Physiol Pharmacol 14: 391- 397. 3. 3. Keeble, J.E., Moore, P.K. (2002) Pharmacology and potential therapeutic applications of nitric oxide-releasing nonsteroidal anti-inflammatory and related nitric oxidedonating drugs. Br J Pharmacol 137: 295-310. 4. 4. Moghadamtousi, S. Z., Abdul Kadir, H.; Hassandarvish, P., Hassan, T., Abubakar, S., Zandi, K (2014) A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin. BioMed Research International. http://dx.doi. org/10.1155/2014/186864. 5. 5. Changtam, C., de Koning, H.P., Ibrahim, H.,Sajid, M. S., Gould, M. K., Suksamrarn, A (2010) Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur. J. Med. Chem 45, 941-956.

Biography :

Adel Al Hidmi obtained his PhD from The Hebrew University of Jerusalem, department of medicinal chemistry & natural products. He is currently working as a research and lecturer at Birzeit University.

E-mail: ahidmi@birzeit.edu