Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
R G Ahmed
Beni Suef University, Egypt
Posters & Accepted Abstracts: J Clin Toxicol
In the last 10 years, there is accumulative interest about chemical pollutants that have the capability to act as hormone simulators. Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane), a chemical frequently found in plastic packing from receipts to the lining of food cans and supposed to interrupt the endocrine system. Although, early-life BPA exposure might influence the maternofetal hypothalamic pituitary thyroid axis (HPTA) and contribute to childhood neural disorders, insufficient studies have examined the associations between BPA exposure and HPTA in pregnant or their offspring. The fetal hypothyroid state owing to the maternal administration of BPA disordered the levels of serum leptin, insulin growth factor 1 (IGF1), adiponectin, insulin, growth hormone (GH) and tumor necrosis factor-Ã?Â? (TNF-Ã?Â?). The reduction in the maternofetal body weight could propose a drop in the overall health level which can be significant in the clarification of HPTA effects. Accordingly, BPA binds to thyroid receptor (TR) and diminishes triiodothyronine (T3)-mediated gene expression by improving its reaction with the co-repressor N-CoR. These observations indicate that the maternofetal BPA might act as endocrine disruptor producing hypothyroidism and changing the development of the HPTA, the fat metabolism, and the perinatal activity. Finally, maternofetal BPA might exert intricate, mosaic actions during pregnancy, and might have consequences for fetal and neonatal development. Maternal thyroid function ought to be tested cautiously during the gestation, and the annual assessment for fetal/neonatal TSH (a marker of thyroid function), thyroid hormones, and GH would be essential after any disruption in the developing HPTA. Additional experimentations are needed to elucidate the probable relations with human health.