Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Ralph Nicholas Salvatore
University of New England, USA
Posters & Accepted Abstracts: Organic Chem Curr Res
Cesium reagents are well known catalysts for a wide variety of synthetic transformations and the generation of pharmaceutically intermediates. In particular, cesium bases are generally far superior to their alkali metal counterparts with respect to decrease in reaction time and increased product yield. Also, cesium bases have excelled at controlling chemoselectivity and are highly compatible with a wide range of functional groups. This enhanced reactivity under mild conditions has been dubbed as the "cesium effect" stemming from better solubilities and the generation of highly reactive "naked anions". Striking efficiency and versatility of alkylations were found. However, the exact cause of the effect is still, to date, unknown. The first part of this seminar will provide a review of synthetic methodologies for numerous cesium-promoted alkylations developed in our laboratories for the construction of a plethora of carbon-heteroatom bonds. Second, utilizing our cesium base-promoted alkylation methodologies, the synthesis of various macrocycles, novel artificial biomolecules and heterocycles will be discussed
Email: rsalvatore@une.edu