Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Parisa Sarkhail
Tehran University of Medical Sciences, Iran
Posters-Accepted Abstracts: J Pharma Care Health Sys
This review focuses on ethnopharmacological uses of Peucedanum species, as well as the phytochemical, pharmacological and toxicological studies on this genus. Through this review, I intend to highlight the known and potential effects of the Peucedanum species or their isolated compounds and show which of traditional medicine uses have supported by pharmacological investigations. Several bioactive substances, including coumarins, polyphenols, flavonoids, phenolic acids, essential oils, diterpenes and other components, have been isolated from species of Peucedanum. Coumarins and essential oils are considered the main components of almost all Peucedanum plants and can be responsible for many of their biological and pharmacological activities of Peucedanum species such as anti-inflammatory, antidiabetic, anti-platelet aggregation, and antiproliferative activities, cardiopulmonary protection, neuroprotection and phototoxicity. Moreover, because the botanical classification of Peucedanum species by anatomical and morphological features is difficult, chemicals of essential oils and coumarins have been valuable as chemotaxonomic markers. In this review, I explain the importance of some coumarins, such as praeruptorins A and B, for preventing or treating cancer, cardiovascular problems and some inflammatory diseases. In conclusion, some Peucedanum species have emerged as a good source of the traditional medicine for treatment of inflammation, microbial infections and cardiopulmonary diseases and provides new insights for further investigations on isolated compounds specially on praeruptorins to find novel therapeutics and drug discovery. However, for uses of Peucedanum species to prevent and treat various diseases, the additional pharmacological studies to find the mechanism of action, safety and efficacy of them before starting clinical trials are required.
Email: sarkhail@sina.tums.ac.ir