Translational Medicine
Open Access
ISSN: 2161-1025
+44 1223 790975
ISSN: 2161-1025
+44 1223 790975
Norio K Ishida
Scientific Tracks Abstracts: Transl Med
The behavior and physiology of most organisms show circadian, 24-hour rhythmicity. Genetic analysis has revealed several clock genes which are responsible for rhythm generation. At molecular level, mammalian circadian oscillator is driven by a cell autonomous transcription / translation-based negative feedback loop, wherein positive elements (CLOCK and BMAL1) induce the expression of negative regulators (Periods, CRY1 and CRY2) that inhibit the transactivation of positive regulators in the central clock (SCN) in brain as well as peripheral tissue clocks. Recent research reveals that this clock feedback loop affects many aspects of our physiology, such as cancer, infarction and obesity. In this lecture, I will present several topics of chronobiology application including 1) The role of sleep abnormalities for predicting of Parkinson�s disease. . 2) CLOCK regulates the circadian expression of peroxisome proliferator-activated receptor �± (PPAR �± ) mRNA. 3) PPAR �± agonist, Bezafibrate advanced the sleep phase of delayed phase syndrome (DSPS) mice. This suggests PPARa is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.
Norio K Ishida completed his Ph.D. in Physiological Chemistry from Kyoto University, Faculty of Medicine (c/o Prof. Tasuku.Honjo) 1986 Institute of Molecular and Cell Biology, Agency of Industrial Science and Technology (AIST), Ministry of International Trade and Industry (MITI) 1989-Principal Investigator, Visiting Scientist c/o Prof. Erkki Rouslahti ,Cancer Research Center (The Burnham Institute), La Jolla Cancer Foundation, CA, U.S.A, 1999-2004 Professor, Department of Biomolecular Engineering, Tokyo Institute of Technology, 2004-now Professor* and Distinguished PI, Clock Cell Biology, Institute of Applied Biochemistry, University of Tsukuba, Japan.