Journal of Sleep Disorders & Therapy
Open Access

Clinical and sleep characteristics of patients with OSA and low respiratory arousal threshold: Aging and obesity

Annual Summit on Sleep Disorders & Medicine

August 10-12, 2015 San Francisco, USA

Carlos Alberto Viegas and Cesar Augusto Melo-Silva

University of Brasilia, Brazil

Posters-Accepted Abstracts: J Sleep Disord Ther

Abstract :

Introduction: Obstructive sleep apnea (OSA) is a serious and common disease with important cardiovascular and neurocognitive consequences. Despite of that, the treatment of OSA remains unsatisfactory because of inconsistent efficacy and variable adherence to existing therapies. So, to identify patients with low arousal threshold could help to find an alternative treatment using a more individualized therapeutic approach. Objective: To identify clinical characteristics and polysomnographics of patients with OSA and low arousal threshold and the influence of obesity and aging. Methods: We reviewed the baseline overnight polysomnograms performed between 2013 and 2014 in a private sleep laboratory. We included patients with OSA (AHI>5/h) and clinical predictors of low respiratory arousal threshold with age range between 30 and 60 years old. Were excluded patients with morbid obesity was (BMIâ�¥40 Kg/m2). The total group was divided into three groups according the decades of age (30-39, 40-49 and 50-60 years old) and into two groups according to the BMI (25-29 and 30-39 Kg/m2). Results: Were reviewed polysomnograms of 275 patients, 160 men. The average age and body mass index for the entire group were: 44.7�±7.9 years (range 30-60) and 30.2�±3.8 Kg/m2 (range 25-39). The sleep characteristics were: SES=8.9�±4.8 points (range 1-24); %N1 (% total sleep time)=3.7�±2.3% (range 0.1-13.8); %N2 (% total sleep time)=70.2�±10.2% (range 41.6-94.2); %N3 (% total sleep time)=7.9�±6.1% (range 0.0-27.5); %REM (%total sleep time)=17.8�±6.4% (range 2.5-36.0); arousal index (arousals/h of sleep)=16.0�±9.0 (range 1.5-55.0); AHI (/hour)=12.4�±6.5/hour (range 5.0-29.0); apneas (no.)=19.3�±20.4 (range 0.0-113) and; hypopneas (no.)=58.7�±35.8 (range 1.0-176); nadir SpO2 (%)=84.4�±2.7% (range 80-92). In none of the studied variables there was statistically significant difference (p>0.05) between obese and no obese patients and in the different decades of live. Conclusion: The aging and the weight do not change the sleep characteristics of patients with OSA and low arousal threshold.

Biography :

Email: viegasc@uol.com.br