Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
+44 1300 500008
ISSN: 2157-7013
+44 1300 500008
Muhammed Rauf Ahmed
Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan
Posters & Accepted Abstracts: J Cell Sci Ther
Regrettably, the occurrences of burns are common, leading to scarring or death. Plateletrich plasma (PRP) is enriched in growth factors, can enhance wound repair. We analyzed the use of PRP in deep second degree burns in rats. Fifty Westar rats divided into five groups, ten rats were being used as a control, ten rats received PRP, ten rats received cells spray and ten rats received a combination of PRP and cells spray. After 20days, rats were sacrificed and skin biopsies were collected. Wounds treated with PRP combined with cells showed earlier wound repair, reduction in CD31-, CD68-, CD163-, MPO- and in TGF-β- positive cells and an increase in MMP2-positive cells. The neo-epidermis was thinner in the control of both groups and granulation tissue was less reduced in the control of both groups. These results indicate that PRP and cells can speed up the healing process in second-degree burns.
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