Translational Medicine
Open Access
ISSN: 2161-1025
+44 1223 790975
ISSN: 2161-1025
+44 1223 790975
Gholson Lyon
Scientific Tracks Abstracts: Transl Med
As a practicing child, adolescent and adult psychiatrist, I have met numerous families caring for severely disabled members of the family, and there is a genetic basis for these disorders in many instances. To enable the revolution in individualized medicine and personal genomics, I urge here the need for clinical-grade sample collection, high-quality sequencing data acquisition, digitalized phenotyping, rigorous generation of variant calls, and comprehensive functional annotation of variants. Additionally, I argue that a �networking of science� model that encourages much more collaboration and online sharing of medical history, genomic data and biological knowledge, including among research participants and patients, will help establish causation and penetrance for disease causal variants and genes. As we enter this new era of genomic medicine, I envision that consumer-driven and consumer-oriented efforts will take center stage, thus translating the human genome project directly back to each person on an individual level
Gholson Lyon, M.D. Ph.D., is an assistant professor in human genetics at Cold Spring Harbor Laboratory and a research scientist at the Utah Foundation for Biomedical Research. He is also a board-certified child, adolescent and adult psychiatrist. In addition to his research on the genetics of neuropsychiatric illnesses, He is focusing on the genetic basis of rare Mendelian diseases.