Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Nicholas Christoforidis
Embryolab IVF Unit, Greece
Posters & Accepted Abstracts: Endocrinol Metab Syndr
Polycystic ovarian syndrome is associated with a high risk of ovarian hyperstimulation syndrome (OHSS) in women seeking fertility treatment and undergoes assisted reproduction with IVF. OHSS is the single most serious complication of controlled ovarian stimulation with a wide range of manifestations, including life-threatening complications. The use of short protocols with gonadotropin releasing hormones (GnRH)-antagonists to achieve multiple follicular developments, has enabled the substitution of human chorionic gonadotropin (hCG) for final oocyte maturation with GnRH analogues, rendering the possibility of OHSS development extremely low. However, implantation rates in the same cycle following GnRH analogue trigger have not been satisfactory. In this context, the elective cryopreservation of embryos has been proposed as a safe means to avoid OHSS, at the same time, high implantation rates can be achieved with embryo transfer in a subsequent cycle, following endometrial preparation. The use of vitrification as a cryopreservation method of choice has been associated with extremely high post warming embryo survival rates. Our experience in Embryo lab Fertility Clinic is presented between 2012 and 2015, following the introduction of the "elective freeze-all strategy" as a means to provide a safe and effective IVF treatment in women with PCOS. Results suggest that moderate to severe OHSS can be eliminated, while embryo quality is not compromised following vitrification and warming of embryos for transfer. Clinical pregnancy rate appears at least as good as in fresh embryo transfers.
Email: n.christoforidis@me.com