Journal of Clinical Trials
Open Access

Design, graph theoretical analysis, in silico modeling and synthesis of biologically active pyrimidines as antimicrobial and antitubercular agent

8^th Global Pharmacovigilance & Drug Safety Summit

JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA

Theivendren Panneerselvam and Jithendar Reddy Mandhadi

Kalasalingam University, India
Satavahana University, India

Posters & Accepted Abstracts: J Clin Trial

Abstract :

A series of 1-(2-(6-(4- substituted benzyl)-2-amino-5-carbamoylpyrimidin-4-yloxy) acetyl) thiosemicarbazide (S 1-25) 1-(2- (6-(4- substituted benzyl)-2-amino-5-carbamoyl pyrimidin-4-yloxy)acetyl) semicarbazide (R 1-25) were developed using different aromatic aldehydes, urea and thiourea. The synthesized compounds were characterized by IR, 1H-NMR and mass spectrometry and these constitute attractive targets for the development of active antimicrobial as well as antimycobacterial agent. Among the compounds tested both electron withdrawing and releasing compounds exhibited significant antibacterial and antifungal activities while unsubstituted compounds also showed notable antifungal activity with reference to standard drugs Clotrimazole. The most active and selective compounds carry a fluorine atom in the phenyl ring at para-position. In conclusion, the potency and selectivity of these compounds make them valid lead compounds for synthesizing new analogues.

Biography :

Email: tpsphc@gmail.com