Rheumatology: Current Research
Open Access

Development of a composite by bone implant “Poliapatita® EPO” with neovascularization properties

International Conference and Exhibition on Orthopedics & Rheumatology

August 13-15, 2012 Hilton Chicago/Northbrook, USA

Haney Castro Fern�ndez, Oscar E. Ledea and Julio C�sar Garc�a

Posters: Rheumatology & Orthopedics

Abstract :

A problem to be solved by modern society is associated with the development of biomaterials for prosthetic, replacement of organs and body functions that have been damaged by accident or deterioration associated with increasing of the life expectancy. One of the implant materials that have become most interesting because of its high biocompatibility and osteoconductive nature is hydroxyapatite from marine coral (Coralina� HAP-200). The Coralina� HAP-200 has three dimensional interconnected pores similar to the trabecular bone. These pores have diameters between 200 - 300 μm; allowing the proliferation of tissue within the implant, favoring an adequate vascularization and a perfectly bone integration. Poliapatita� is a composite formed by HAP-200, CaCO3 and POVIAc�. In this composite are combined the properties of hydroxyapatite and the capacity of controlled drug delivery exhibit by the polymer POVIAc�. The nature of the biomolecule to be release it is also important in the final properties of composite. The aim of this work was the ?Development of a biomaterial for bone implants, composed by Poliapatita� - Erythropoietin (EPO) with neovascularizantion properties?