Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Ana Isabel Fraguas Sanchez, Ana Isabel Torres Suarez and Ana Maria Fernandez Carballido
Universidad Complutense de Madrid, Spain
Posters-Accepted Abstracts: J Pharma Care Health Sys
Cannabidiol (CBD) is the major non-psychotropic cannabinoid presents in Cannabis sativa plant. It has proved to have a potential therapeutic utility in several kinds of tumors, due to its ability to inhibit or reduce the proliferation, adhesion, migration and invasion of cancer cells and to induce apoptotic effects. Breast cancer is one of the tumors where CBD has shown a high anticancer activity. However, despite its potential clinical interest it is difficult to develop an effective formulation with CBD because it has a low aqueous solubility and several stability problems. Systems as nanoparticles (NPs) may resolve these questions, and also may increase antitumor activity of cannabidiol. The aim of this work was to develop biodegradable nanospheres loaded with CBD for parenteral administration for the treatment of breast cancer. NPs were elaborated using poly-D, L-lactide-co-glycolide resomer (PLGA 502�®) by nano-precipitation technique and were characterized in terms of morphology, particle size, zeta potential, drug loading, entrapment efficiency and in vitro drug release. Formulations with 10% and 20% of CBD were prepared. Spherical, nonporous and uniform NPs were obtained, showing a particle size below 200 nm and a high drug loading and entrapment efficiency. The antitumor activity was also evaluated in vitro using MDA-MB-231 cell line as a model of breast cancer.
Cannabidiol (CBD) is the major non-psychotropic cannabinoid presents in Cannabis sativa plant. It has proved to have a potential therapeutic utility in several kinds of tumors, due to its ability to inhibit or reduce the proliferation, adhesion, migration and invasion of cancer cells and to induce apoptotic effects. Breast cancer is one of the tumors where CBD has shown a high anticancer activity. However, despite its potential clinical interest it is difficult to develop an effective formulation with CBD because it has a low aqueous solubility and several stability problems. Systems as nanoparticles (NPs) may resolve these questions, and also may increase antitumor activity of cannabidiol. The aim of this work was to develop biodegradable nanospheres loaded with CBD for parenteral administration for the treatment of breast cancer. NPs were elaborated using poly-D, L-lactide-co-glycolide resomer (PLGA 502®) by nano-precipitation technique and were characterized in terms of morphology, particle size, zeta potential, drug loading, entrapment efficiency and in vitro drug release. Formulations with 10% and 20% of CBD were prepared. Spherical, nonporous and uniform NPs were obtained, showing a particle size below 200 nm and a high drug loading and entrapment efficiency. The antitumor activity was also evaluated in vitro using MDA-MB-231 cell line as a model of breast cancer.
Email: anaisabelfraguas@gmail.com