Current Synthetic and Systems Biology
Open Access

Development of tools for mammalian gene circuit design and performance control

2^nd International Conference on Systems & Synthetic Biology

August 18-20, 2016 London, UK

Velia Siciliano

Imperial College London, UK

Posters & Accepted Abstracts: Curr Synthetic Sys Biol

Abstract :

Synthetic biology aims at developing and applying engineering tools to sense and process endogenous information and to implement robust responses to intracellular conditions. Mammalian synthetic networks build on the conjugation of efforts to increase the number of DNA parts for genetic circuit assembly with minimal counteractive effect with the intracellular context with the ability to design circuits that are activated when specific endogenous molecules are sensed within the cells. I will show our results on designing new genetic parts such as transcriptional activators and repressor in mammalian cells and circuits based on RNA binding proteins as a new potential platform of gene delivery and genetic circuit regulation. Finally I will describe the design of protein sensors as mean to trigger cell-selective circuit activation.

Biography :

Email: velias@mit.edu