Journal of Clinical Toxicology
Open Access

DNA abasic lesion is cleaved by antibiotic drugs aminoglycosides: A promising effect that could potentiate antitumor genotoxic agents

6^th Global Summit on Toxicology & Applied Pharmacology

October 17-19, 2016 Houston, USA

Maralise Perigolo de Oliveira, Jean-Francois Constant, Marine Peuchmaur, Ivan Pitta and Jean-Luc Decout

University of Grenoble, France

Posters & Accepted Abstracts: J Clinic Toxicol

Abstract :

Abasic sites are probably the most common lesions in DNA. They result from the hydrolytic cleavage of glycosidic bonds that can occur spontaneously and during the repair processes of damaged nucleic bases produced by anticancer alkylating agents and radiotherapy. If not repaired, the abasic site can be mutagenic or lethal. Thus, compounds able to specifically bind and react to abasic sites have attracted much attention for therapeutic and diagnostic purposes. Here, we report on the efficient cleavage activity of natural aminoglycosides (AG) antibiotic drugs at abasic sites. Neomycin B appeared to be the most efficient compound (EC50=0.1�¼M). This cleavage activity could be related to the aminoglycoside toxicity but could also find medicinal applications through potentiation of cancer radiotherapy and chemotherapy with alkylating drugs.

Biography :

Maralise Perígolo de Oliveira has completed her Master’s from University Grenoble Alpes and PhD from Pernambuco Federal University (Brazil) in 2014. Since 2015, she is involved in her Post-doctoral research in Medicinal Chemistry from Belo Horizonte (Brazil) through collaboration from Pernambuco Federal University and Federal University of Minas Gerais.

Email: maraperigolo@hotmail.com