Journal of Hepatology and Gastrointestinal disorders
Open Access
ISSN: 2475-3181
+44-77-2385-9429
ISSN: 2475-3181
+44-77-2385-9429
Isaac Moses Danat and Ruoling Chen
University of Wolverhampton, UK
Posters & Accepted Abstracts: J Hepatol Gastroint Dis
Statement of the Problem: There is a debate on whether overweight and obesity in older age increase or reduce the risk of latelife dementia. Little is known on gender differences in the impacts of overweight and obesity in older age on the risk of dementia. Methodology: We examined data from the Anhui cohort of 3336 participants aged â?¥65 years who were randomly recruited from the urban and rural communities, China. Using a standard method, we interviewed them to record general health and risk factors, measure body weight, height and waist circumference (WC) and diagnose dementia. They were followed up until 2011 in 3 surveys at 1, 7 and 10 years after baseline. Findings: Among 2,430 participants with no baseline dementia, 271 developed dementia over 10 years follow-up. Compared to those with BMI<24 kg/m2, multivariate adjusted odd ratio (OR) for incident dementia in participants with overweight (BMI 24â?¤28.0) and obesity (BMIâ?¥28) were 1.06 (95% CI 0.79-1.42) and 1.00 (0.63-1.57). The matched figures in men were 2.16 (1.33- 3.51) and 2.63 (1.28-5.42) and in women 0.66 (0.45-0.98) and 0.52 (0.28-0.97), respectively. After excluding data of â?¤1-year incident dementia, these ORs in men were 3.09 (1.65-5.77) and 4.19 (1.75-10.03) and in women 0.74 (0.43-1.27) and 0.72 (0.32- 1.64). Data from WC showed similar patterns of the impacts of overweight and obesity on risk of dementia. Interpretation: Overweight and obesity in older age increased the risk of late-life dementia in men but not in women. Controlling body weigh in older age may prevent dementia worldwide.
E-mail: I.M.Danat@wlv.ac.uk