Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Berezhnaya Irina Vladimirovna and Zakharova Irina Nikolaevna
Russian Medical Academy of Continuous Professional Education, Russia
Posters & Accepted Abstracts: Pediatr Ther
Objective: To study the detectability of eosinophilic colitis in children with colitis syndrome. Materials & Methods: In profi le gastroenterological department of a large children's hospital for 10 years examined 300 children have applied colitis syndrome. When conducting a comprehensive survey among 101 children diagnosed chronic colitis. By the conclusion of the morphological diagnosis of IBD was proved in 59 children, of whom 22 UC in 5 BC and 32 undiff erentiated colitis (UC). However, in 42 patients with colitis syndrome by morphological data revealed eosinophilic colitis (EC). In comparative evaluation of the early history of children from group EC revealed an earlier onset of artifi cial feeding (2 - 2.5 months) than in the group of children with IBD. On the background of the early introduction of adapted milk formula in 78.6% of children (n = 33) with EC marked manifestations of food allergy to a year. Allergic symptoms are characterized by increased frequency of vomiting 88% (n = 37), intestinal colic buildup 92.8% (n = 39), 33.3% manifestations atopic dermatitis children (n = 14). When analyzing the history of the development revealed that 57.1% (n = 24) a family history holds asthma, atopic dermatitis in the immediate family. At 30.9% (n = 13) food intolerance (milk, chicken and egg) from one of the parents. In this group, signifi cantly more frequently (n = 31), 73.8% higher than in children with IBD (n = 17), 28.8% found to have iron defi ciency anemia, the genesis of which is not installed. In the primary treatment carried out a comprehensive survey of children with IBD and EC groups, which included a complete blood count, determination of ferritin, serum iron, total protein, CRP, Ig E, Ig M, Ig A, IL-6, IL-10, endoscopy and CFS biopsy. Th e children in group EC structure colon mucosa and submucosal infi ltration of eosinophils is more signifi cant and less neutrophils. Of the group of 42 children EC only 19% of children (n = 8) revealed elevated levels of total IgE, the rest of this children group total IgE levels were within the age norm. In clinical analysis of blood eosinophilia detected in only 38% (n = 16) that had no signifi cant diff erences in the group of children with IBD (35.5% - n = 21) (p <0.5). Catamnesis held for 10 years, the children of the EC group at UC 8 proved two of which form of castration. Of the 36 patients with EC hypoallergenic diet observed only 8.3% (n = 3), worsening of the disease was noted in the fi rst year of observation, aft er 5 years of complaints, these children did not show. Children who have not complied with hypoallergenic diet aft er 2 years of follow-3 development of asthma in 25 children saved gastrointestinal allergy manifestations: acute attacks of abdominal pain, vomiting, diarrhea with an admixture of large amounts of mucus and blood. Abdominal pain worse when consuming dairy products and disappear against the background of a strict diet. In 15 children during the observation period were observed with the increase in skin rashes colitis and dyspeptic syndrome. Conclusion: In children with a history of Allergoanamnez on protein products (cow's milk protein, chicken protein) may develop colitis syndrome on a background of allergic colitis genesis. Under strict dietary recommendations with the exception of the products revealed the complete disappearance of symptoms. According to a ten-year follow-up, children who did not comply elimination diet preserved manifestations of iron defi ciency anemia, gastrointestinal allergy with periods expressed gemokolita, while 3 of them developing asthma during the fi rst 2 years of observation. Given the almost identical clinical picture of the disease beginning in children with IBD and EC development of UC during the fi rst 5 years of observation, it is advisable to recommend the exclusion from the diet of foods containing milk and chicken protein. Children with otyagoschennyem аllergoanamnez necessary medical appointment hypoallergenic mixtures in order to prevent the development of food allergies.
Berezhnaya Irina Vladimirovna is an Associate Professor of the Department of Pediatrics of the Russian Medical Academy of Continuing Vocational Education.