Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Waseem F Al-Tameemi
Al-Nahrain University, Iraq
Scientific Tracks Abstracts: J Hematol Thrombo Dis
Background: Chronic transfusions program in β-Thalassemia patients will inevitably lead to iron overload with a significant morbidity and mortality. Glomerular Filteration: Rate(GFR) is progressively declined in relation to iron overload as well as chronic anemia. Objective: Objective is to define levels of Cystatin C in transfusion dependent β-Thalassemia Major patients as a sensitive marker for detection of earlier glomerular dysfunction in addition to understand the effect of iron overload ,chelating therapy and hepatitis infection. Patients and method: A cross sectional study conducted at Al-Basrah hemoglobinopathy Centre for the period from September 2017 to January 2018 to enroll 75 β-Thalassemia Major patients . Data collected included duration of the disease, total transfusion requirement, details of chelation therapy and its therapeutic index. In addition to blood urea, serum creatinine and Cystatin C with Estimated glomerular filtration rate (eGFR). Results: The mean Cystatin C was 1.075mg/l where 66.6% of patients had abnormal renal function which is higher proportion than those with renal (42.6%) detected according to serum creatinine level Cystatin C was significantly higher in patients who received desferrioxamine as compared to those received deferasirox (p =0.007), in accordance with GFR which is significantly higher in patients receiving the latter chelation therapy (p=0.009). A significant inverse relationship between Cystatin C, and GFR, while positive relationship between ferritin and Cystatin C (p= 0.0001, 0.001 respectively). Conclusion: Cyctatin C is better for detection and monitoring of glomerular dysfunction in B thalassemia major patient which is already not uncommon complications for the disease and iron chelation therapy.
Publications:
1. Ali BA, Mahmoud AM. Frequency of glomerular dysfunction in children with beta thalassaemia major. Sultan Qaboos Univ Med J 2014;14:e88.
2. Hannemann A, Friedrich N, Dittmann K, et al. Age-and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate. Clin Chem Lab Med 2012;50: 919-26.
3. Papassotiriou I, Margeli A, Hantzi E, et al. Cystatin C levels in patients with β- thalassemia during deferasirox treatment. Blood Cells Mol Dis 2010;44: 152-5.